Lipid Profile, Apolipoproteins A and B in Children With Epilepsy

In this study, lipid profile was assessed, and the intimal wall thickness of both carotid arteries in children with idiopathic epilepsy was measured. The study comprised 22 children with idiopathic epilepsy on either carbamazepine or valproate. A profile including triglycerides, total cholesterol, l...

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Bibliographic Details
Published in:Journal of child neurology 2008-11, Vol.23 (11), p.1275-1281
Main Authors: Tomoum, Hoda Yahya, Awadallah, Maha Mohammed, Fouad, Dina Adel, Ali, Ahmed Hanafy
Format: Article
Language:English
Subjects:
Anticonvulsants - therapeutic use
Apolipoproteins A - metabolism
Apolipoproteins B - metabolism
Carbamazepine - therapeutic use
Case-Control Studies
Child
Child, Preschool
Cholesterol, HDL - metabolism
Cholesterol, LDL - metabolism
Cross-Sectional Studies
Epilepsy - drug therapy
Epilepsy - metabolism
Epilepsy - pathology
Female
Humans
Lipid Metabolism - drug effects
Lipid Metabolism - physiology
Lipids
Male
Triglycerides - metabolism
Valproic Acid - therapeutic use
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Summary:In this study, lipid profile was assessed, and the intimal wall thickness of both carotid arteries in children with idiopathic epilepsy was measured. The study comprised 22 children with idiopathic epilepsy on either carbamazepine or valproate. A profile including triglycerides, total cholesterol, low-density and high-density lipoproteins cholesterol, apolipoproteins AI and B, and Duplex estimation of intimal wall thickness of carotid arteries were performed. Patients on carbamazepine showed increase in total cholesterol, low-density and high-density lipoproteins cholesterol, and decrease in apolipoprotein AI levels compared with controls. Levels of total cholesterol, low-density lipoproteins cholesterol, and apolipoprotein AI were reduced in patients receiving valproate compared with controls, whereas total cholesterol, high-density lipoproteins cholesterol, and apolipoprotein AI were reduced compared with those receiving carbamazepine. Carotid arteries intimal wall thickness was not significantly changed in any of the studied groups. Although atherogenic ratios are not changed, the lowered apolipoprotein AI levels may suggest an increased risk for coronary heart disease.
ISSN:0883-0738
1708-8283
DOI:10.1177/0883073808318538