Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection

Background Although endoscopic submucosal dissection (ESD) is expected to reduce the local recurrence of gastric cancers, we still experience cases of recurrence after an ESD. Objective To characterize clinical and pathologic features of cases with local recurrence of early gastric cancer after an E...

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Published in:Gastrointestinal endoscopy 2008-11, Vol.68 (5), p.887-894
Main Authors: Takenaka, Ryuta, MD, Kawahara, Yoshiro, MD, Okada, Hiroyuki, MD, Hori, Keisuke, MD, Inoue, Masafumi, MD, Kawano, Seiji, MD, Tanioka, Daisuke, MD, Tsuzuki, Takao, MD, Yagi, Satoru, MD, Kato, Jun, MD, Uemura, Masayuki, MD, Ohara, Nobuya, MD, Yoshino, Tadashi, MD, Imagawa, Atsushi, MD, Fujiki, Shigeatsu, MD, Takata, Rie, MD, Yamamoto, Kazuhide, MD
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Biological and medical sciences
Gastric Mucosa - surgery
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Gastroscopy
Humans
Medical sciences
Neoplasm Recurrence, Local - etiology
Neoplasm Recurrence, Local - surgery
Risk Factors
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Background Although endoscopic submucosal dissection (ESD) is expected to reduce the local recurrence of gastric cancers, we still experience cases of recurrence after an ESD. Objective To characterize clinical and pathologic features of cases with local recurrence of early gastric cancer after an ESD. Design A prospective cohort study. Setting and Patients A total of 306 patients with gastric cancers removed by ESD at Okayama University Hospital and Tsuyama Central Hospital between March 2001 and December 2005 were enrolled. Intervention ESD. Main Outcome Measurement Local recurrence. Results The incidence of a complete en bloc resection was 80.4% when pathologically evaluated. Within a median follow-up period of 26 months (12-64 months), a local recurrence was found in 7 cases, all of which had been declared incomplete resections. One patient underwent a second ESD, and the remaining 6 underwent a surgical resection. All removed lesions were mucosal cancers. No lymph-node metastases were found in patients with a surgical resection. There was a significant correlation between the incidence of an incomplete resection and that of a local recurrence ( P < .0001). Among the clinical characteristics, tumor size (>30 mm vs
ISSN:0016-5107
1097-6779
DOI:10.1016/j.gie.2008.03.1089