Depressed Adolescents Grown Up

• Published in: JAMA : the journal of the American Medical Association 1999-05, Vol.281 (18), p.1707-1713
• Main Authors: Weissman, Myrna M, Wolk, Susan, Goldstein, Risë B, Moreau, Donna, Adams, Philip, Greenwald, Steven, Klier, Claudia M, Ryan, Neal D, Dahl, Ronald E, Wickramaratne, Priya
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Adults; Age of Onset; Biological and medical sciences; Case-Control Studies; Depression; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - therapy; Disease Progression; Female; Follow-Up Studies; Humans; Male; Medical research; Medical sciences; Mental depression; Mood disorders; Prospective Studies; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk; Statistics, Nonparametric; Suicide - statistics & numerical data; Suicide, Attempted - statistics & numerical data; Teenagers
• ISSN: 0098-7484; 1538-3598
• DOI: 10.1001/jama.281.18.1707

CONTEXT Major depressive disorder (MDD) that arises in adolescence impairs functioning and is associated with suicide risk, but little is known about its continuity into adulthood. OBJECTIVE To describe the clinical course of adolescent-onset MDD into adulthood. DESIGN AND PARTICIPANTS Prospective case-control study. Seventy-three subjects had onset of MDD based on systematic clinical assessment during adolescence (Tanner stage III-V) and 37 controls had no evidence of past or current psychiatric disorders, and also were assessed in adolescence (assessment years: 1977-1985). Follow-up was conducted 10 to 15 years after the initial assessment by an independent team without knowledge of initial diagnosis (follow-up years: 1992-1996). SETTING Cases were identified at Columbia Presbyterian Hospital, New York City, NY; controls were recruited from the community. MAIN OUTCOME MEASURES Suicide and suicide attempts, psychiatric diagnoses, treatment utilization, and social functioning. RESULTS Clinical outcomes of adolescent-onset MDD into adulthood compared with control subjects without psychiatric illness include a high rate of suicide (7.7%); a 5-fold increased risk for first suicide attempt; a 2-fold increased risk of MDD, but not other psychiatric disorders; an increased occurrence of psychiatric and medical hospitalization; and impaired functioning in work, social, and family life. Thirty-seven percent of those with adolescent MDD survived without an episode of MDD in adulthood vs 69% of the control participants (relative risk, 2.2 [95% confidence interval, 1.0-4.7; P