Synthesis and Properties of (6,7-Dimethoxy-4-coumaryl)alanine: A Fluorescent Peptide Label

The synthesis of racemic andl-(6,7-dimethoxy-4-coumaryl)alanine (Dmca) is described and some spectral and physicochemical properties are reported. The utility of Dmca as a highly sensitive and specific label for the quantitative detection of synthetic peptides in HPLC and in minimal essential media...

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Bibliographic Details
Published in:Analytical biochemistry 1999-05, Vol.270 (1), p.15-23
Main Authors: Bennett, Fiona A., Barlow, David J., Dodoo, Alexander N.O., Hider, Robert C., Lansley, Alison B., Lawrence, M.Jayne, Marriott, Christopher, Bansal, Sukhvinder S.
Format: Article
Language:English
Subjects:
Alanine - analogs & derivatives
Alanine - chemical synthesis
Alanine - chemistry
Coumarins - chemical synthesis
Coumarins - chemistry
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Isomerism
Models, Chemical
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
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Description
Summary:The synthesis of racemic andl-(6,7-dimethoxy-4-coumaryl)alanine (Dmca) is described and some spectral and physicochemical properties are reported. The utility of Dmca as a highly sensitive and specific label for the quantitative detection of synthetic peptides in HPLC and in minimal essential media (MEM) is also described.
ISSN:0003-2697
1096-0309
DOI:10.1006/abio.1999.4081