Genetic causes of impaired wound healing. Rare differential diagnosis of the non-healing wound

Chronic leg ulcers affect about 1% of the German population. The intense search for the underlying cause of impaired wound healing is an essential requirement for successful therapy. The most common causes comprise chronic venous insufficiency (70%), peripheral arterial occlusive disease (10%) and d...

Full description

Saved in:
Bibliographic Details
Published in:Hautarzt 2008-11, Vol.59 (11), p.893-903
Main Authors: Elsharkawi-Welt, K, Hepp, J, Scharffetter-Kochanek, K
Format: Article
Language:ger
Subjects:
Diagnosis, Differential
Genetic Predisposition to Disease
Humans
Leg Ulcer - diagnosis
Leg Ulcer - genetics
Leg Ulcer - therapy
Wounds and Injuries - diagnosis
Wounds and Injuries - genetics
Wounds and Injuries - therapy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic leg ulcers affect about 1% of the German population. The intense search for the underlying cause of impaired wound healing is an essential requirement for successful therapy. The most common causes comprise chronic venous insufficiency (70%), peripheral arterial occlusive disease (10%) and diabetes mellitus. Besides vasculitis, infectious diseases and tumors, genetic diseases may constitute the underlying cause for impaired wound healing. In this review various rare genetic diseases causing chronic wounds like the Klinefelter-Syndrome, immunological diseases including the TAP-deficiency-syndrome and the leukocyte adhesion deficiency-syndromes, red blood cell disorders, thalassemia, thrombotic diseases, progeroid syndromes and inherited connective tissue disorders are presented.
ISSN:1432-1173
DOI:10.1007/s00105-008-1591-2