Evaluation of reference tissue model and tissue ratio method for 5-HTT using [123 I] ADAM tracer

Abstract The serotonin (5-hydroxytryptamine, or 5-HT) transporters (5-HTT) are target-sites for commonly used antidepressants. [123 I] ADAM is a novel radiotracer that selectively binds the 5-HTT of the central nervous system. The aim for this study was to compare four-parameter model (FPM) with thr...

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Bibliographic Details
Published in:Computer methods and programs in biomedicine 2008-12, Vol.92 (3), p.294-298
Main Authors: Yang, Bang-Hung, Wang, Shyh-Jen, Chou, Yuan-Hwa, Su, Tung-Ping, Chen, Shih-Pei, Lee, Jih-Shian, Chen, Jyh-Cheng
Format: Article
Language:English
Subjects:
5-HTT
[ 123I] ADAM
Adult
Algorithms
Binding potential
Cerebellum - diagnostic imaging
Cerebellum - metabolism
Cinanserin - analogs & derivatives
Cinanserin - pharmacokinetics
Female
Humans
Internal Medicine
Magnetic Resonance Imaging
Male
Models, Biological
Other
Protein Binding
Radiopharmaceuticals - pharmacokinetics
Reference tissue model
Serotonin Plasma Membrane Transport Proteins - metabolism
Serotonin transporters
Specific uptake ratio
SPECT
Tissue Distribution
Tomography, Emission-Computed, Single-Photon
Young Adult
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Summary:Abstract The serotonin (5-hydroxytryptamine, or 5-HT) transporters (5-HTT) are target-sites for commonly used antidepressants. [123 I] ADAM is a novel radiotracer that selectively binds the 5-HTT of the central nervous system. The aim for this study was to compare four-parameter model (FPM) with three-parameter model (TPM) from non-invasive reference tissue model (RTM) for 5-HTT quantification using the cerebellum as indirect input function. Furthermore, we compared tracer kinetic model with the tissue ratio (TR) method. The binding potential (BP) values derived from both models were almost the same, but ratio of delivery ( R1 ) in TPM had smaller standard deviation than the FPM. There was also significant correlation between BP and specific uptake ratio (SUR). In conclusion, simplified reference tissue model (SRTM) was the better choice because of its stability and convenient implementation for non-invasive quantification of brain SPECT studies. The correlation found between BP and SUR supports the use of TR method for quantification of 5-HTT to avoid arterial sampling in dynamic SPECT scan.
ISSN:0169-2607
1872-7565
DOI:10.1016/j.cmpb.2008.02.011