Comparison of methods for determination of glomerular filtration rate: low and high-dose Tc-99m-DTPA renography, predicted creatinine clearance method, and plasma sample method

The gamma camera uptake method with Tc-99m-DTPA (diethylenetriaminepentaacetic acid) is a simple method for determination of glomerular filtration rate (GFR), and is less time-consuming than other methods, but its diagnostic accuracy is debated. Gate’s method (low-dose; LD), the high-dose method (HD...

Full description

Saved in:
Bibliographic Details
Published in:International urology and nephrology 2008, Vol.40 (4), p.1059-1065
Main Authors: Assadi, Majid, Eftekhari, Mohammad, Hozhabrosadati, Mehrdad, Saghari, Mohsen, Ebrahimi, Abdolali, Nabipour, Iraj, Abbasi, Mohammad Zaki, Moshtaghi, Darab, Abbaszadeh, Moloud, Assadi, Sakineh
Format: Article
Language:English
Subjects:
Adolescent
Adult
Creatinine - blood
Female
Gamma Cameras
Glomerular Filtration Rate
Humans
Kidney - diagnostic imaging
Kidney Diseases - blood
Kidney Diseases - diagnostic imaging
Kidney Function Tests
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nephrology - Original Paper
Radioisotope Renography - methods
Radiopharmaceuticals
Regression Analysis
Technetium Tc 99m Pentetate
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The gamma camera uptake method with Tc-99m-DTPA (diethylenetriaminepentaacetic acid) is a simple method for determination of glomerular filtration rate (GFR), and is less time-consuming than other methods, but its diagnostic accuracy is debated. Gate’s method (low-dose; LD), the high-dose method (HD), the predicted-clearance method, and the plasma-clearance method with Tc-99m-DTPA are compared in this study. We also performed GFR measurement and diuretic renography simultaneously. Tc-99m DTPA renography was performed in 36 patients aged 18–72 years with a wide range of renal function (serum creatinine 1.37 ± 0.49 mg/dl). GFR was determined by four methods: the gamma camera uptake method with low-dose Tc-99m DTPA (Gates, LD); the gamma camera uptake method with high-dose Tc-99m DTPA (HD); the predicted creatinine clearance method (Cockcroft–Gualt, CG); and the plasma sample clearance (PSC) method using a mono-exponential curve. The PSC method was chosen as reference. The regression equations for the CG, Gates (low-dose), and HD methods against the PSC method were 28.68 + 0.80 X ( r  = 0.72; P value 
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-008-9446-4