Reaction of rat brain capillaries to immobilization stress

The calcium adenosine triphosphate method of Chilingaryan was used to study the morphofunctional state of the capillary component of the microcirculatory bed of the brain in rats at different time points after experimental immobilization stress (fixation of the animal on its back for 2 h). Analysis...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2008-11, Vol.38 (9), p.929-931
Main Author: Danielyan, M. A.
Format: Article
Language:English
Subjects:
Aggression
Animals
Behavior
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Blood vessels
Brain
Capillaries - anatomy & histology
Cerebral Cortex - blood supply
Gene expression
Histamine
Homeostasis
Immobilization
Microcirculation
Nervous system
Neurobiology
Neurosciences
Physiology
Rats
Stress, Physiological
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Summary:The calcium adenosine triphosphate method of Chilingaryan was used to study the morphofunctional state of the capillary component of the microcirculatory bed of the brain in rats at different time points after experimental immobilization stress (fixation of the animal on its back for 2 h). Analysis of morphometric data showed that in comparison with intact animals, stress was immediately followed by constriction of capillaries by 17.2%, with compensatory dilation by 2.5% occurring at two days, and subsequent minor constriction by 5.6%. Morphometric measures in placid and aggressive animals showed that the behavioral stereotype of placid animals produced a more sparing physiological response to stress. It is suggested that the difference in capillary dysfunction is largely dependent on impairment of neuronal systems involved in regulating the microcirculation.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-008-9078-2