Endometrial stromal sarcomas : Immunohistochemical, electron microscopical and cytogenetic findings in two cases

Uterine sarcomas are approximately 3% of all malignant uterine corpus tumours. Of these, the tumours that originate solely in the stromal elements of the uterine wall are infrequent and have not been well characterized cytogenetically. We report two cases of endometrial stromal sarcomas (ESS), one l...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1999-04, Vol.434 (4), p.307-314
Main Authors: GIL-BENSO, R, LOPEZ-GINES, C, NAVARRO, S, CARDA, C, LLOMBART-BOSCH, A
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers, Tumor - analysis
Chromosome Aberrations - genetics
Chromosome Banding
Chromosome Disorders
Chromosomes, Human, Pair 20 - genetics
Chromosomes, Human, Pair 6 - genetics
Combined Modality Therapy
Endometrial Neoplasms - chemistry
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Endometrial Neoplasms - therapy
Fatal Outcome
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunoenzyme Techniques
Karyotyping
Medical sciences
Microscopy, Electron
Middle Aged
Sarcoma, Endometrial Stromal - chemistry
Sarcoma, Endometrial Stromal - genetics
Sarcoma, Endometrial Stromal - pathology
Sarcoma, Endometrial Stromal - therapy
Tumors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Uterine sarcomas are approximately 3% of all malignant uterine corpus tumours. Of these, the tumours that originate solely in the stromal elements of the uterine wall are infrequent and have not been well characterized cytogenetically. We report two cases of endometrial stromal sarcomas (ESS), one low grade and one high grade, diagnosed by conventional histology, immunocytochemistry, electron microscopy and cytogenetics. Morphologically clear-cut differential structures were seen at optical, immunohistochemical, and electron microscopic levels, permitting a clear differential diagnosis. The low-grade ESS expressed hormonal receptors and vimentin, whereas the high-grade ESS showed no hormone receptors, high Ki-67 activity, and occasional cytokeratin-positive cells. Ultrastructurally, no malignant epithelial differentiation was seen in the tumour cells, but cilia were found in both cases. Cytogenetic study of the low-grade ESS showed pseudodiploid karyotype with chromosomes 6 and 20 rearranged. The high-grade ESS showed a complex karyotype with clonal numerical and structural anomalies. The chromosomes involved in the structural rearrangements were 1, 3, 6, 7, 13, 14, 15, 17, 19, and 21.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050346