Study on novel hydrogels based on thermosensitive PNIPAAm with pH sensitive PDMAEMA grafts

A series of novel hydrogels based on poly( N-isopropylacrylamide) (PNIPAAm) with pendant poly( N-(2-(dimethylamino) ethyl)-methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of...

Full description

Saved in:
Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2008-12, Vol.67 (2), p.245-252
Main Authors: Wang, Zong-Chun, Xu, Xiao-Ding, Chen, Chang-Sheng, Wang, Gan-Rui, Wang, Bo, Zhang, Xian-Zheng, Zhuo, Ren-Xi
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Calorimetry, Differential Scanning
Controlled release
Hydrogels - chemistry
Hydrogen-Ion Concentration
Kinetics
Methacrylates - chemistry
Microscopy, Electron, Scanning
Nylons - chemistry
Pendant PDMAEMA
pH sensitive
PNIPAAm hydrogel
Temperature
Thermosensitive
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of novel hydrogels based on poly( N-isopropylacrylamide) (PNIPAAm) with pendant poly( N-(2-(dimethylamino) ethyl)-methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of morphology observed by scanning electron microscopy (SEM), thermal property characterized by differential scanning calorimetry (DSC) and shrinking/swelling kinetics upon external temperature changes. In comparison with the conventional PNIPAAm hydrogels, resulting hydrogels presented favorable pH sensitivity as well as improved thermosensitive properties, including enlarged water containing capability at room temperature and faster shrinking/swelling rate upon heating. In addition, fish DNA, used as a model drug, was loaded into the hydrogels, and the controlled release behavior of the drug-loaded hydrogels at different temperatures (22 and 37 °C) was further studied.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2008.09.002