Study on novel hydrogels based on thermosensitive PNIPAAm with pH sensitive PDMAEMA grafts

A series of novel hydrogels based on poly( N-isopropylacrylamide) (PNIPAAm) with pendant poly( N-(2-(dimethylamino) ethyl)-methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of...

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Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2008-12, Vol.67 (2), p.245-252
Main Authors: Wang, Zong-Chun, Xu, Xiao-Ding, Chen, Chang-Sheng, Wang, Gan-Rui, Wang, Bo, Zhang, Xian-Zheng, Zhuo, Ren-Xi
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Calorimetry, Differential Scanning
Controlled release
Hydrogels - chemistry
Hydrogen-Ion Concentration
Kinetics
Methacrylates - chemistry
Microscopy, Electron, Scanning
Nylons - chemistry
Pendant PDMAEMA
pH sensitive
PNIPAAm hydrogel
Temperature
Thermosensitive
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cited_by cdi_FETCH-LOGICAL-c393t-41c33043cabecaa2fce7776eac2a3355ce5517cc9659defcc2b9e25b13c439003
cites cdi_FETCH-LOGICAL-c393t-41c33043cabecaa2fce7776eac2a3355ce5517cc9659defcc2b9e25b13c439003
container_end_page 252
container_issue 2
container_start_page 245
container_title Colloids and surfaces, B, Biointerfaces
container_volume 67
creator Wang, Zong-Chun
Xu, Xiao-Ding
Chen, Chang-Sheng
Wang, Gan-Rui
Wang, Bo
Zhang, Xian-Zheng
Zhuo, Ren-Xi
description A series of novel hydrogels based on poly( N-isopropylacrylamide) (PNIPAAm) with pendant poly( N-(2-(dimethylamino) ethyl)-methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of morphology observed by scanning electron microscopy (SEM), thermal property characterized by differential scanning calorimetry (DSC) and shrinking/swelling kinetics upon external temperature changes. In comparison with the conventional PNIPAAm hydrogels, resulting hydrogels presented favorable pH sensitivity as well as improved thermosensitive properties, including enlarged water containing capability at room temperature and faster shrinking/swelling rate upon heating. In addition, fish DNA, used as a model drug, was loaded into the hydrogels, and the controlled release behavior of the drug-loaded hydrogels at different temperatures (22 and 37 °C) was further studied.
doi_str_mv 10.1016/j.colsurfb.2008.09.002
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subjects Acrylic Resins - chemistry
Calorimetry, Differential Scanning
Controlled release
Hydrogels - chemistry
Hydrogen-Ion Concentration
Kinetics
Methacrylates - chemistry
Microscopy, Electron, Scanning
Nylons - chemistry
Pendant PDMAEMA
pH sensitive
PNIPAAm hydrogel
Temperature
Thermosensitive
title Study on novel hydrogels based on thermosensitive PNIPAAm with pH sensitive PDMAEMA grafts
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