Does concomitant injection of a combined diphtheria-tetanus-acellular pertussis : hepatitis B virus : inactivated polio virus vaccine influence the reactogenicity and immunogenicity of commercial Haemophilus influenzae type b conjugate vaccines?

Does concomitant injection of a combined diphtheria-tetanus-acellular pertussis - hepatitis B virus - inactivated polio virus vaccine influence the reactogenicity and immunogenicity of commercial Haemophilus influenzae type b conjugate vaccines? The immunogenic responses and local reactions to four...

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Published in:European journal of pediatrics 1999-05, Vol.158 (5), p.398-402
Main Authors: USONIS, V, BAKASENAS, V
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - biosynthesis
Antibodies, Viral - biosynthesis
Bacterial Capsules
Bacterial Proteins - administration & dosage
Bacterial Proteins - immunology
Biological and medical sciences
Diphtheria-Tetanus-acellular Pertussis Vaccines
Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage
Diphtheria-Tetanus-Pertussis Vaccine - immunology
Epidemiology. Vaccinations
General aspects
Haemophilus Vaccines - administration & dosage
Haemophilus Vaccines - immunology
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - immunology
Humans
Infant
Infectious diseases
Medical sciences
Poliovirus Vaccine, Inactivated - administration & dosage
Poliovirus Vaccine, Inactivated - immunology
Polysaccharides, Bacterial - administration & dosage
Polysaccharides, Bacterial - immunology
Tetanus Toxoid - administration & dosage
Tetanus Toxoid - immunology
Vaccination - adverse effects
Vaccines, Combined - administration & dosage
Vaccines, Combined - immunology
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - immunology
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BAKASENAS, V
description Does concomitant injection of a combined diphtheria-tetanus-acellular pertussis - hepatitis B virus - inactivated polio virus vaccine influence the reactogenicity and immunogenicity of commercial Haemophilus influenzae type b conjugate vaccines? The immunogenic responses and local reactions to four Haemophilus influenzae type b (Hib) conjugate vaccines licensed for primary immunisation (Hiberix, ActHib, Pedvax, HibTITER) when administered concomitantly but in the opposite thigh with a candidate diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine were studied in 549 healthy infants at 3, 4.5 and 6 months of age. Local reactions were mild, but different between the four groups, a tetanus conjugate Hib vaccine showing the fewest reactions. All local reactions resolved without sequelae. There was no apparent general reaction. The immunogenic response was similar with all four vaccines, geometric mean concentrations ranging from 4.95 to 7.2 microg/ml. All but one subject had antipolyribosylribitol phosphate polysaccharide antibody titres > or =0.15 microg/ml, and 88.0% to 96% achieved high titres (>1.0 microg/ml) generally associated with long-term protection against Hib disease. There does not appear to be any interference with the immune response when current commercial Haemophilus influenzae type b conjugate vaccines are concomitantly administered with a candidate diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus vaccine as separate injections.
doi_str_mv 10.1007/s004310051100
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The immunogenic responses and local reactions to four Haemophilus influenzae type b (Hib) conjugate vaccines licensed for primary immunisation (Hiberix, ActHib, Pedvax, HibTITER) when administered concomitantly but in the opposite thigh with a candidate diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine were studied in 549 healthy infants at 3, 4.5 and 6 months of age. Local reactions were mild, but different between the four groups, a tetanus conjugate Hib vaccine showing the fewest reactions. All local reactions resolved without sequelae. There was no apparent general reaction. The immunogenic response was similar with all four vaccines, geometric mean concentrations ranging from 4.95 to 7.2 microg/ml. All but one subject had antipolyribosylribitol phosphate polysaccharide antibody titres &gt; or =0.15 microg/ml, and 88.0% to 96% achieved high titres (&gt;1.0 microg/ml) generally associated with long-term protection against Hib disease. 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The immunogenic responses and local reactions to four Haemophilus influenzae type b (Hib) conjugate vaccines licensed for primary immunisation (Hiberix, ActHib, Pedvax, HibTITER) when administered concomitantly but in the opposite thigh with a candidate diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine were studied in 549 healthy infants at 3, 4.5 and 6 months of age. Local reactions were mild, but different between the four groups, a tetanus conjugate Hib vaccine showing the fewest reactions. All local reactions resolved without sequelae. There was no apparent general reaction. The immunogenic response was similar with all four vaccines, geometric mean concentrations ranging from 4.95 to 7.2 microg/ml. All but one subject had antipolyribosylribitol phosphate polysaccharide antibody titres &gt; or =0.15 microg/ml, and 88.0% to 96% achieved high titres (&gt;1.0 microg/ml) generally associated with long-term protection against Hib disease. There does not appear to be any interference with the immune response when current commercial Haemophilus influenzae type b conjugate vaccines are concomitantly administered with a candidate diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus vaccine as separate injections.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>10333123</pmid><doi>10.1007/s004310051100</doi><tpages>5</tpages></addata></record>
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ispartof European journal of pediatrics, 1999-05, Vol.158 (5), p.398-402
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1432-1076
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subjects Antibodies, Bacterial - biosynthesis
Antibodies, Viral - biosynthesis
Bacterial Capsules
Bacterial Proteins - administration & dosage
Bacterial Proteins - immunology
Biological and medical sciences
Diphtheria-Tetanus-acellular Pertussis Vaccines
Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage
Diphtheria-Tetanus-Pertussis Vaccine - immunology
Epidemiology. Vaccinations
General aspects
Haemophilus Vaccines - administration & dosage
Haemophilus Vaccines - immunology
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - immunology
Humans
Infant
Infectious diseases
Medical sciences
Poliovirus Vaccine, Inactivated - administration & dosage
Poliovirus Vaccine, Inactivated - immunology
Polysaccharides, Bacterial - administration & dosage
Polysaccharides, Bacterial - immunology
Tetanus Toxoid - administration & dosage
Tetanus Toxoid - immunology
Vaccination - adverse effects
Vaccines, Combined - administration & dosage
Vaccines, Combined - immunology
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - immunology
title Does concomitant injection of a combined diphtheria-tetanus-acellular pertussis : hepatitis B virus : inactivated polio virus vaccine influence the reactogenicity and immunogenicity of commercial Haemophilus influenzae type b conjugate vaccines?
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