Echoplanar chemical shift imaging

• Published in: Magnetic resonance in medicine 1999-05, Vol.41 (5), p.877-882
• Main Authors: Guimaraes, A.R., Baker, J.R., Jenkins, B.G., Lee, P.L., Weisskoff, R.M., Rosen, B.R., González, R.G.
• Format: Article
• Language: English
• Subjects: Aspartic Acid - analogs & derivatives; Aspartic Acid - analysis; Biological and medical sciences; Body Water - chemistry; Brain - metabolism; chemical shift imaging; Choline - analysis; Creatine - analysis; Echo-Planar Imaging - methods; echoplanar imaging; Fourier Analysis; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Spectroscopy - methods; Medical sciences; N-acetyl aspartate; Nervous system; neurodegeneration; Phantoms, Imaging; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Signal Processing, Computer-Assisted; Time Factors
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/(SICI)1522-2594(199905)41:5<877::AID-MRM4>3.0.CO;2-3

A novel method of chemical shift imaging utilizing echoplanar imaging (EPI) has been developed for the purpose of improving the spatial resolution of metabolite images for the specific goal of high spatial resolution mapping of neuronal content. An EPI sequence was modified to allow temporal offsets of the 180° refocusing pulse that encode the chemical shift information into the phase of the signal. Implementation of this method on 1.5 and 3 T human imagers has resulted in images of N‐acetyl aspartate in humans with spatial resolution of 360μl and signal‐to‐noise ratio ∼7:1 in less than 13 min. Magn Reson Med 41:877–882, 1999. © 1999 Wiley‐Liss, Inc.