Synthesis of Ginseng Diyne Analogues and Their Antiproliferative Activity against L1210 Cells

Some analogues of Ginseng diyne were synthesized and tested for antiproliferative activity against L1210 cells. The epoxy moiety of panaxydol, isolated from the root of Panax ginseng, proved to be in the cis‐form on comparison with synthetic specimens. Analysis of structure‐activity relationship rev...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 1999-04, Vol.332 (4), p.133-136
Main Authors: Kim, S I, Lee, Y H, Ahn, B Z
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - therapeutic use
antiproliferative activity
Biological and medical sciences
configuration of epoxy moiety
Epoxy diyne derivatives
General aspects
Leukemia L1210 - drug therapy
Medical sciences
Panax - therapeutic use
Pharmacology. Drug treatments
Phytotherapy
Plants, Medicinal
Structure-Activity Relationship
Tumor Cells, Cultured
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Summary:Some analogues of Ginseng diyne were synthesized and tested for antiproliferative activity against L1210 cells. The epoxy moiety of panaxydol, isolated from the root of Panax ginseng, proved to be in the cis‐form on comparison with synthetic specimens. Analysis of structure‐activity relationship revealed that the presence of the heptadec‐1‐ene‐4,6‐diyn‐3‐ol moiety in the structure of the analogues was essential for their antiproliferative activity and that the epoxy and alkyl groups in the structure contributed to enhancement of the antiproliferative activity.
ISSN:0365-6233
1521-4184
DOI:10.1002/(SICI)1521-4184(19994)332:4<133::AID-ARDP133>3.0.CO;2-G