Stiffness index identifies patients with osteoporotic fractures better than ultrasound velocity or attenuation alone

Objectives: To compare a composite ultrasonometry variable, the stiffness index (SI), with its two component variables of speed of sound (SOS) and broadband ultrasound attenuation (BUA), in identifying post-menopausal women with low bone mineral density (BMD) and/or osteoporotic fracture. Methods: A...

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Bibliographic Details
Published in:Maturitas 1999-03, Vol.31 (3), p.221-226
Main Authors: Hadji, P., Hars, O., Wüster, Chr, Bock, K., Alberts, U.-S., Bohnet, H.-G., Emons, G., Schulz, K.-D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone
Bone Density
Cross-Sectional Studies
Diseases of the osteoarticular system
Female
Fracture
Fractures, Spontaneous - diagnostic imaging
Fractures, Spontaneous - epidemiology
Fractures, Spontaneous - etiology
Humans
Medical sciences
Middle Aged
Osteoporosis
Osteoporosis, Postmenopausal - complications
Osteoporosis, Postmenopausal - diagnostic imaging
Osteoporosis, Postmenopausal - epidemiology
Osteoporosis. Osteomalacia. Paget disease
Retrospective Studies
Risk Factors
ROC Curve
Ultrasonography
Ultrasonometry
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Summary:Objectives: To compare a composite ultrasonometry variable, the stiffness index (SI), with its two component variables of speed of sound (SOS) and broadband ultrasound attenuation (BUA), in identifying post-menopausal women with low bone mineral density (BMD) and/or osteoporotic fracture. Methods: A cross sectional sample of 1217 women (mean (S.D.) age 53.9 (9.7) years) was studied. Risk factors for osteoporosis were assessed by detailed questionnaire and women with diseases, or those taking treatments known to affect bone metabolism were excluded. Women were allocated to one of four groups: pre-menopausal women ( n=476), healthy post-menopausal women ( n=583), post-menopausal women with low BMD ( n=101), and post-menopausal women with osteoporotic fracture ( n=57). An Achilles ultrasonometer was used to perform quantitative ultrasonometry (QUS) at the os calcis. The SI, calculated mathematically from SOS and BUA, was computed. Results: Analysis of receiver operating curves (ROC) between healthy post-menopausal women and post-menopausal women with low BMD but no fracture, showed that the area under the curve (AUC) for SI was significantly greater than that for BUA ( P
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(99)00003-1