Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue

• Published in: The Journal of nutritional biochemistry 2008-12, Vol.19 (12), p.840-847
• Main Authors: Nomura, Sachiko, Ichinose, Takashi, Jinde, Manabu, Kawashima, Yu, Tachiyashiki, Kaoru, Imaizumi, Kazuhiko
• Format: Article
• Language: English
• Subjects: Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Animals; Biological and medical sciences; Body Weight - drug effects; Brown adipose tissue; Catechin - analogs & derivatives; Catechin - pharmacology; Energy Intake - drug effects; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; High-fat diet; Ion Channels - drug effects; Ion Channels - genetics; Male; Membrane Transport Proteins - genetics; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins - drug effects; Mitochondrial Proteins - genetics; Mitochondrial Uncoupling Proteins; Nerve Tissue Proteins - genetics; Normal-fat diet; Rats; Rats, Sprague-Dawley; RNA, Messenger - genetics; Tea; Tea catechins; Uncoupling Protein 1; Uncoupling Protein 2; Uncoupling Protein 3; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/j.jnutbio.2007.11.005

The aim of the present study was to determine whether the antiobesity effects of tea catechins (TCs) are associated with the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT). Male Sprague–Dawley rats were fed a high-fat (HF; 35% fat) diet for 5 weeks, then divided into four groups and fed an HF, HF with 0.5% TC (HFTC), normal-fat (NF; 5% fat) or NF with 0.5% TC (NFTC) diet for 8 weeks. At the end of the experimental period, perirenal and epididymal white adipose tissues (WATs) and interscapular BAT were isolated. The NFTC group had significantly lower perirenal WAT weights than the NF group (NF: 12.7±0.53 g; NFTC: 10.2±0.43 g; P