Motor outcome prediction using diffusion tensor tractography in pontine infarct

We investigated whether the integrity of the corticospinal tract classified by diffusion tensor tractography (DTT) can predict the motor outcome in 25 patients with pontine infarct. DTTs were obtained in the early stage of stroke (5–30 days) and were classified into two groups (type A: the integrity...

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Bibliographic Details
Published in:Annals of neurology 2008-10, Vol.64 (4), p.460-465
Main Authors: Jang, Sung Ho, Bai, Daiseg, Son, Su Min, Lee, Jun, Kim, Dae-Shik, Sakong, Joon, Kim, Dong Gyu, Yang, Dong Seok
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Brain Infarction - pathology
Brain Infarction - physiopathology
Brain Mapping
Chi-Square Distribution
Diffusion Magnetic Resonance Imaging
Extremities - physiopathology
Female
Humans
Image Processing, Computer-Assisted
Male
Medical sciences
Middle Aged
Motor Activity - physiology
Neurology
Pons - pathology
Predictive Value of Tests
Psychomotor Performance - physiology
Pyramidal Tracts - pathology
Pyramidal Tracts - physiopathology
Vascular diseases and vascular malformations of the nervous system
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Summary:We investigated whether the integrity of the corticospinal tract classified by diffusion tensor tractography (DTT) can predict the motor outcome in 25 patients with pontine infarct. DTTs were obtained in the early stage of stroke (5–30 days) and were classified into two groups (type A: the integrity of corticospinal tract was preserved around the infarct; type B: corticospinal tract was interrupted). DTT type A patients showed better motor function than the type B patients at 6 months after onset. DTT obtained at the early stage of pontine infarct appears to have predictive value for motor outcome in patients with pontine infarct. Ann Neurol 2008
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.21444