Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1

The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008-12, Vol.18 (23), p.6214-6217
Main Authors: CHEUNG, M, KUNTZ, K. W, SMITH, J. L, SMITH, G. K, LANSING, T. J, MOOK, R. A, POBANZ, M, SALOVICH, J. M, WILSON, B. J, ANDREWS, C. W, SHEWCHUK, L. M, EPPERLY, A. H, HASSLER, D. F, LEESNITZER, M. A
Format: Article
Language:English
Subjects:
Administration, Oral
Amines - chemical synthesis
Amines - chemistry
Amines - pharmacology
Analytical, structural and metabolic biochemistry
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cell Cycle Proteins - antagonists & inhibitors
Combinatorial Chemistry Techniques
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Imidazoles - chemical synthesis
Imidazoles - chemistry
Imidazoles - pharmacology
Medical sciences
Mice
Miscellaneous
Models, Molecular
Molecular Conformation
Molecular Structure
Pharmacology. Drug treatments
Polo-Like Kinase 1
Protein Serine-Threonine Kinases - antagonists & inhibitors
Proto-Oncogene Proteins - antagonists & inhibitors
Structure-Activity Relationship
Transferases
Triazines - chemical synthesis
Triazines - chemistry
Triazines - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2008.09.100