The prevalence of the platelet glycoprotein IIIa Pl(A1/A2) polymorphism in three South African ethnic groups and its effect on platelet function

In South Africa coronary artery disease (CAD) is less common in African than Indian or white subjects. Although the association between CAD and metabolic factors have been well documented, the role of genetic factors is as yet poorly understood. Specific polymorphisms in the platelet membrane glycop...

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Bibliographic Details
Published in:Thrombosis research 2008-01, Vol.123 (2), p.316-323
Main Authors: Naran, Nitien H, Chetty, Nanthakumarn, Crowther, Nigel J
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - agonists
Adenosine Diphosphate - pharmacology
Alleles
Blood Platelets - metabolism
Collagen - agonists
Collagen - pharmacology
Coronary Artery Disease - genetics
Coronary Artery Disease - metabolism
Dose-Response Relationship, Drug
Ethnic Groups - genetics
Female
Gene Frequency
Genotype
Humans
Integrin beta3 - genetics
Male
Platelet Aggregation - physiology
Polymorphism, Genetic
Prevalence
South Africa - ethnology
Thromboxane A2 - analysis
Thromboxane A2 - biosynthesis
Thromboxane A2 - metabolism
Urban Population
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Summary:In South Africa coronary artery disease (CAD) is less common in African than Indian or white subjects. Although the association between CAD and metabolic factors have been well documented, the role of genetic factors is as yet poorly understood. Specific polymorphisms in the platelet membrane glycoprotein (GP) IIIa gene Pl(A1/A2), have been implicated in the development of CAD. The prevalence of platelet GPIIIa (Pl(A1/A2)) polymorphisms and their effect on platelet function was determined in 313 Indian, 267 white and 227 African subjects with and without a history of CAD. In subjects without a history of CAD the frequency of the unfavourable Pl(A2) allele was 8.0%, 14.8% and 8.7% in the Indian, white and African populations respectively, with the frequency being significantly higher (p
ISSN:0049-3848
DOI:10.1016/j.thromres.2008.06.007