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Plasma urokinase receptor levels in patients with colorectal cancer : Relationship to prognosis
The proteolytic enzyme plasmin, which is generated from the precursor plasminogen by the action of urokinase plasminogen activator, is thought to play a role in tumor cell invasion and metastasis. Urokinase plasminogen activator receptor (uPAR) is functionally involved in the cell surface activation...
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| Published in: | JNCI : Journal of the National Cancer Institute 1999-05, Vol.91 (10), p.869-874 |
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| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 91 |
| creator | STEPHENS, R. W NIELSEN, H. J CHRISTENSEN, I. J THORLACIUS-USSING, O SØRENSEN, S DANØ, K BRÜNNER, N |
| description | The proteolytic enzyme plasmin, which is generated from the precursor plasminogen by the action of urokinase plasminogen activator, is thought to play a role in tumor cell invasion and metastasis. Urokinase plasminogen activator receptor (uPAR) is functionally involved in the cell surface activation (i.e., cleavage) of plasminogen. Increased tumor tissue levels of uPAR are associated with poor prognosis in several types of cancer. This retrospective study was undertaken to test the relationship between preoperative plasma levels of soluble uPAR (suPAR) and survival in patients with colorectal cancer.
suPAR levels in preoperative plasma from 591 patients with colorectal cancer were determined by use of a kinetic enzyme-linked immunosorbent assay and analyzed with respect to associations with postoperative survival, Dukes' stage, age, and serum carcinoembryonic antigen level. Plasma suPAR measurements were log transformed for survival analysis, which employed the Kaplan-Meier method and the Cox proportional hazards model. All P values reported are two-sided.
Univariate analysis, using the log-transformed suPAR concentrations, demonstrated that there was an increasing risk of mortality with increasing plasma suPAR level (P |
| doi_str_mv | 10.1093/jnci/91.10.869 |
| format | article |
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suPAR levels in preoperative plasma from 591 patients with colorectal cancer were determined by use of a kinetic enzyme-linked immunosorbent assay and analyzed with respect to associations with postoperative survival, Dukes' stage, age, and serum carcinoembryonic antigen level. Plasma suPAR measurements were log transformed for survival analysis, which employed the Kaplan-Meier method and the Cox proportional hazards model. All P values reported are two-sided.
Univariate analysis, using the log-transformed suPAR concentrations, demonstrated that there was an increasing risk of mortality with increasing plasma suPAR level (P<.0001). An arbitrary cut point, the median for all patients (1.37 ng/mL), divided patients with Dukes' stage B, C, or D disease into statistically different prognostic groups. In multivariate Cox analysis including Dukes' stage, age, and carcinoembryonic antigen level, the suPAR concentration independently predicted survival (P<.0001).
The preoperative plasma suPAR level independently predicted survival of patients with colorectal cancer. Further studies of plasma suPAR in patients with cancer are needed to evaluate the utility of plasma suPAR measurements and cut points in identifying high-risk patients among those with early stage disease.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/91.10.869</identifier><identifier>PMID: 10340907</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Age Factors ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Carcinoembryonic Antigen - blood ; Colorectal cancer ; Colorectal Neoplasms - blood ; Enzyme Precursors - blood ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical research ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Plasma ; Plasminogen Activators - blood ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Receptors, Cell Surface - blood ; Receptors, Urokinase Plasminogen Activator ; Retrospective Studies ; Risk ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Tumors</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1999-05, Vol.91 (10), p.869-874</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Superintendent of Documents May 19, 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-1c1fd42a0544c89a610f41c8064c4f44b931ed2fa116b40a71d27ea9828953643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1941132$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10340907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STEPHENS, R. W</creatorcontrib><creatorcontrib>NIELSEN, H. J</creatorcontrib><creatorcontrib>CHRISTENSEN, I. J</creatorcontrib><creatorcontrib>THORLACIUS-USSING, O</creatorcontrib><creatorcontrib>SØRENSEN, S</creatorcontrib><creatorcontrib>DANØ, K</creatorcontrib><creatorcontrib>BRÜNNER, N</creatorcontrib><title>Plasma urokinase receptor levels in patients with colorectal cancer : Relationship to prognosis</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>The proteolytic enzyme plasmin, which is generated from the precursor plasminogen by the action of urokinase plasminogen activator, is thought to play a role in tumor cell invasion and metastasis. Urokinase plasminogen activator receptor (uPAR) is functionally involved in the cell surface activation (i.e., cleavage) of plasminogen. Increased tumor tissue levels of uPAR are associated with poor prognosis in several types of cancer. This retrospective study was undertaken to test the relationship between preoperative plasma levels of soluble uPAR (suPAR) and survival in patients with colorectal cancer.
suPAR levels in preoperative plasma from 591 patients with colorectal cancer were determined by use of a kinetic enzyme-linked immunosorbent assay and analyzed with respect to associations with postoperative survival, Dukes' stage, age, and serum carcinoembryonic antigen level. Plasma suPAR measurements were log transformed for survival analysis, which employed the Kaplan-Meier method and the Cox proportional hazards model. All P values reported are two-sided.
Univariate analysis, using the log-transformed suPAR concentrations, demonstrated that there was an increasing risk of mortality with increasing plasma suPAR level (P<.0001). An arbitrary cut point, the median for all patients (1.37 ng/mL), divided patients with Dukes' stage B, C, or D disease into statistically different prognostic groups. In multivariate Cox analysis including Dukes' stage, age, and carcinoembryonic antigen level, the suPAR concentration independently predicted survival (P<.0001).
The preoperative plasma suPAR level independently predicted survival of patients with colorectal cancer. Further studies of plasma suPAR in patients with cancer are needed to evaluate the utility of plasma suPAR measurements and cut points in identifying high-risk patients among those with early stage disease.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - blood</subject><subject>Enzyme Precursors - blood</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Plasma</subject><subject>Plasminogen Activators - blood</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Receptors, Cell Surface - blood</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNpd0M9rHCEUwHEJDcnmx7XHIiX0Nhufus7YWwlpGggklOQsrus0bl2d-mYa8t_XZRca4kWEj0_5EvIR2ByYFpfr5MKlhnqYd0ofkBlIxRoObPGBzBjjbdN1rTwmJ4hrVpfm8ogcAxOSadbOiHmIFjeWTiX_Dsmip8U7P4y50Oj_-og0JDrYMfg0In0J4zN1OeaKRhups8n5Qr_Snz5WkxM-h4GOmQ4l_0oZA56Rw95G9Of7_ZQ8fb9-vPrR3N3f3F59u2ucaNXYgIN-JbllCyldp60C1ktwHVPSyV7KpRbgV7y3AGopmW1hxVtvdcc7vRBKilPyZTe3vvxn8jiaTUDnY7TJ5wmN0m2rlNjCz-_gOk8l1b8ZXrMJ1YGuaL5DrmTE4nszlLCx5dUAM9vuZtvdaNiea_d64dN-6rTc-NUbvgtdwcUeWHQ29qWWC_jfaQkguPgH7xqLJQ</recordid><startdate>19990519</startdate><enddate>19990519</enddate><creator>STEPHENS, R. W</creator><creator>NIELSEN, H. J</creator><creator>CHRISTENSEN, I. 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J ; THORLACIUS-USSING, O ; SØRENSEN, S ; DANØ, K ; BRÜNNER, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-1c1fd42a0544c89a610f41c8064c4f44b931ed2fa116b40a71d27ea9828953643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - blood</topic><topic>Enzyme Precursors - blood</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Plasma</topic><topic>Plasminogen Activators - blood</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Receptors, Cell Surface - blood</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STEPHENS, R. W</creatorcontrib><creatorcontrib>NIELSEN, H. J</creatorcontrib><creatorcontrib>CHRISTENSEN, I. J</creatorcontrib><creatorcontrib>THORLACIUS-USSING, O</creatorcontrib><creatorcontrib>SØRENSEN, S</creatorcontrib><creatorcontrib>DANØ, K</creatorcontrib><creatorcontrib>BRÜNNER, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STEPHENS, R. W</au><au>NIELSEN, H. J</au><au>CHRISTENSEN, I. J</au><au>THORLACIUS-USSING, O</au><au>SØRENSEN, S</au><au>DANØ, K</au><au>BRÜNNER, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma urokinase receptor levels in patients with colorectal cancer : Relationship to prognosis</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>1999-05-19</date><risdate>1999</risdate><volume>91</volume><issue>10</issue><spage>869</spage><epage>874</epage><pages>869-874</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>The proteolytic enzyme plasmin, which is generated from the precursor plasminogen by the action of urokinase plasminogen activator, is thought to play a role in tumor cell invasion and metastasis. Urokinase plasminogen activator receptor (uPAR) is functionally involved in the cell surface activation (i.e., cleavage) of plasminogen. Increased tumor tissue levels of uPAR are associated with poor prognosis in several types of cancer. This retrospective study was undertaken to test the relationship between preoperative plasma levels of soluble uPAR (suPAR) and survival in patients with colorectal cancer.
suPAR levels in preoperative plasma from 591 patients with colorectal cancer were determined by use of a kinetic enzyme-linked immunosorbent assay and analyzed with respect to associations with postoperative survival, Dukes' stage, age, and serum carcinoembryonic antigen level. Plasma suPAR measurements were log transformed for survival analysis, which employed the Kaplan-Meier method and the Cox proportional hazards model. All P values reported are two-sided.
Univariate analysis, using the log-transformed suPAR concentrations, demonstrated that there was an increasing risk of mortality with increasing plasma suPAR level (P<.0001). An arbitrary cut point, the median for all patients (1.37 ng/mL), divided patients with Dukes' stage B, C, or D disease into statistically different prognostic groups. In multivariate Cox analysis including Dukes' stage, age, and carcinoembryonic antigen level, the suPAR concentration independently predicted survival (P<.0001).
The preoperative plasma suPAR level independently predicted survival of patients with colorectal cancer. Further studies of plasma suPAR in patients with cancer are needed to evaluate the utility of plasma suPAR measurements and cut points in identifying high-risk patients among those with early stage disease.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>10340907</pmid><doi>10.1093/jnci/91.10.869</doi><tpages>6</tpages></addata></record> |
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| ispartof | JNCI : Journal of the National Cancer Institute, 1999-05, Vol.91 (10), p.869-874 |
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| subjects | Adult Age Factors Aged Biological and medical sciences Biomarkers, Tumor - blood Carcinoembryonic Antigen - blood Colorectal cancer Colorectal Neoplasms - blood Enzyme Precursors - blood Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical research Medical sciences Middle Aged Neoplasm Staging Plasma Plasminogen Activators - blood Predictive Value of Tests Prognosis Proportional Hazards Models Receptors, Cell Surface - blood Receptors, Urokinase Plasminogen Activator Retrospective Studies Risk Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors |
| title | Plasma urokinase receptor levels in patients with colorectal cancer : Relationship to prognosis |
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