New growth hormone secretagogues: C-terminal modified sulfonamide-Analogues of NN703

The C-terminal the orally active growth hormone secretagogue NN703 was changed to prepare analogues with inverse sulfonamides and inverse amides. The compounds showed high activity in a in vitro rat pituitary model. High potent growth hormone secretagogues with inverse sulfonamides and amides at the...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-05, Vol.9 (9), p.1295-1298
Main Authors: Peschke, Bernd, Hansen, Birgit Sehested
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dipeptides - chemical synthesis
Dipeptides - pharmacology
Hormones. Endocrine system
Indoles - chemical synthesis
Kinetics
Medical sciences
Pharmacology. Drug treatments
Rats
Spiro Compounds - chemical synthesis
Sulfonamides - chemical synthesis
Sulfonamides - pharmacology
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Summary:The C-terminal the orally active growth hormone secretagogue NN703 was changed to prepare analogues with inverse sulfonamides and inverse amides. The compounds showed high activity in a in vitro rat pituitary model. High potent growth hormone secretagogues with inverse sulfonamides and amides at the C-terminal were synthesized.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00167-5