Evaluation of immunomodulatory effects of nisin-containing diets on mice

The effect of nisin on the immune response of mice was studied. Nisin (in the form of the commercial preparation Nisaplin) was incorporated in the diet of experimental mice which were fed for 30, 75 or 100 days. Short-term administration of diets containing Nisaplin induced an increase of both CD4 a...

Full description

Saved in:
Bibliographic Details
Published in:FEMS immunology and medical microbiology 1999-05, Vol.24 (1), p.35-42
Main Authors: de Pablo, Manuel A, Gaforio, José J, Gallego, Aurelia M, Ortega, Elena, Gálvez, Antonio M, Alvarez de Cienfuegos López, Gerardo
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Bacteriocin
Bacteriology
Biological and medical sciences
CD4-CD8 Ratio - drug effects
CD4-CD8 Ratio - methods
Chemiluminescence
Cytometry
Dose-Response Relationship, Immunologic
Flow Cytometry
Food Preservatives
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Leukocyte
Leukocyte Count - drug effects
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Mice
Mice, Inbred BALB C
Microbiology
Modulation of the immune response (stimulation, suppression)
Nisin
Nisin - immunology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Phagocytes - immunology
Phagocytes - physiology
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of nisin on the immune response of mice was studied. Nisin (in the form of the commercial preparation Nisaplin) was incorporated in the diet of experimental mice which were fed for 30, 75 or 100 days. Short-term administration of diets containing Nisaplin induced an increase of both CD4 and CD8 T-lymphocyte cell counts and also a decrease of B-lymphocyte counts. After prolonged diet administration, T-cell counts returned to control levels. Normal levels of B-lymphocytes were also reached after prolonged administration of the lower (but not the higher) Nisaplin concentration. The macrophage/monocyte fraction isolated from peripheral blood became significantly increased after long-term administration (100 days) of Nisaplin-containing diets in a concentration-dependent way. Although the number of peritoneal cells was not affected by the diets, the phagocytic activity of peritoneal cells decreased after prolonged administration of low (but not high) Nisaplin doses.
ISSN:0928-8244
1574-695X
DOI:10.1016/S0928-8244(99)00004-8