Long-term efficacy of Humalog® in subjects with Type 1 diabetes mellitus

To evaluate the long-term effectiveness of Humalog insulin in lowering post meal glucose excursions. Twenty young subjects with Type 1 diabetes mellitus (DM) who had received insulin-lispro (Humalog) for a least 1 year (mean +/- SD 1.8+/-1.6 years) were studied on two occasions, 3-14 days apart. The...

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Published in:Diabetic medicine 1999-05, Vol.16 (5), p.384-387
Main Authors: GARG, S. K, ANDERSON, J. H, PERRY, S. V, MACKENZIE, T, KEITH, P, JENNINGS, M. K, HANSEN, M. M, CHASE, H. P
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - metabolism
Cross-Over Studies
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - immunology
Double-Blind Method
Eating
Female
Hormones. Endocrine system
Humans
Hypoglycemic Agents - immunology
Hypoglycemic Agents - therapeutic use
Insulin - analogs & derivatives
Insulin - immunology
Insulin - therapeutic use
Insulin Antibodies - blood
Insulin Lispro
Male
Medical sciences
Pharmacology. Drug treatments
Postprandial Period
Time Factors
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Summary:To evaluate the long-term effectiveness of Humalog insulin in lowering post meal glucose excursions. Twenty young subjects with Type 1 diabetes mellitus (DM) who had received insulin-lispro (Humalog) for a least 1 year (mean +/- SD 1.8+/-1.6 years) were studied on two occasions, 3-14 days apart. They consumed a similar breakfast consisting of 450-600 kCal having fasted overnight. The same amount of human soluble Humulin Regular or Humalog insulin was given 10 min before the meal in a randomized, double-blind fashion. Postprandial glucose excursions at 30, 60, and 120 min were significantly lower (P
ISSN:0742-3071
1464-5491
DOI:10.1046/j.1464-5491.1999.00066.x