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Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4: II. Structure Determination

The absolute structure of a new antibiotic lactonamycin is described. The NMR studies deduced one of four possible structures for the aglycon attached by a rhodinose through glycosidic bond. The stereochemistry of the sugar obtained by an acid hydrolysis was determined to be L-form by measuring opti...

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Bibliographic Details
Published in:Journal of antibiotics 1999/03/25, Vol.52(3), pp.276-280
Main Authors: MATSUMOTO, NAOKI, TSUCHIDA, TOSHIO, NAKAMURA, HIKARU, SAWA, RYUICHI, TAKAHASHI, YOSHIKAZU, NAGANAWA, HIROSHI, IINUMA, HIRONOBU, SAWA, TSUTOMU, TAKEUCHI, TOMIO, SHIRO, MOTOO
Format: Article
Language:English
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Summary:The absolute structure of a new antibiotic lactonamycin is described. The NMR studies deduced one of four possible structures for the aglycon attached by a rhodinose through glycosidic bond. The stereochemistry of the sugar obtained by an acid hydrolysis was determined to be L-form by measuring optical rotation. The stereochemistry of the aglycon was determined by X-ray crystallographic analysis.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.276