Growth Velocity and Interleukin 6 Concentrations in Juvenile Idiopathic Arthritis

Objective To evaluate associations of growth velocity with inflammatory markers and cumulative dose of glucocorticoid in a cohort of patients with juvenile idiopathic arthritis (JIA) followed during 1 year. Methods Seventy-nine patients were evaluated. Disease activity was evaluated by a pediatric r...

Full description

Saved in:
Bibliographic Details
Published in:Journal of rheumatology 2008-11, Vol.35 (11), p.2265-2271
Main Authors: SOUZA, Leticia S, MACHADO, Sandra H, BRENOL, Claiton V, BRENOL, Joao Carlos T, XAVIER, Ricardo M
Format: Article
Language:English
Subjects:
Adolescent
Anthropometry
Arthritis, Juvenile - drug therapy
Arthritis, Juvenile - epidemiology
Arthritis, Juvenile - immunology
Biological and medical sciences
Biomarkers - blood
Child
Diseases of the osteoarticular system
Female
Glucocorticoids - therapeutic use
Growth Disorders - epidemiology
Growth Disorders - immunology
Humans
Inflammatory joint diseases
Interleukin-6 - blood
Linear Models
Male
Medical sciences
Prevalence
Puberty
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To evaluate associations of growth velocity with inflammatory markers and cumulative dose of glucocorticoid in a cohort of patients with juvenile idiopathic arthritis (JIA) followed during 1 year. Methods Seventy-nine patients were evaluated. Disease activity was evaluated by a pediatric rheumatologist. Anthropometric data were classified according to the World Health Organization standards. Tanner growth velocity curves were used; values below the Z-score≤ −2 were considered low growth velocity. Serum concentrations of interleukin 6 (IL-6) were measured by ELISA, and values > 1 pg/ml were considered elevated. Results The prevalence of low growth velocity was 25.3%, and it was associated with active disease on followup visit, elevated IL-6, erythrocyte sedimentation rate and C-reactive protein, and higher cumulative glucocorticoid doses. In the multiple linear regression with growth velocity as the dependent variable, only elevated IL-6 level was independently and negatively associated with growth velocity. Conclusion Low growth velocity is highly prevalent in children with JIA. Elevated IL-6 levels seem to have an important negative influence on growth in these children, while total glucocorticoid exposure appears to be a secondary factor. Key Indexing Terms: JUVENILE IDIOPATHIC ARTHRITIS GROWTH VELOCITY INTERLEUKIN 6
ISSN:0315-162X
1499-2752
DOI:10.3899/jrheum.080199