Chemical Modification of Antibiotic Eremomycin at the Asparagine Side Chain

AA3-Carboxyeremomycin 2, obtained by selective hydrolysis of antibiotic eremomycin was used as a starting compound for the eremomycin chemical modifications at the asparagine side chain to be transformed into eremomycin AA3, AA7 bis-amides (3a-c). Bis-benzylamide 3b displayed an activity (8μg/ml) ag...

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Bibliographic Details
Published in:Journal of antibiotics 1999/03/25, Vol.52(3), pp.319-324
Main Authors: OLSUFYEYA, EUGENIA N., BERDNIKOVA, TATIANA F., MIROSHNIKOVA, OLGA V., REZNIKOVA, MARINA I., PREOBRAZHENSKAYA, MARIA N.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Asparagine - chemistry
Bacterial Proteins - genetics
Carbon-Oxygen Ligases - genetics
Chromatography, High Pressure Liquid
Drug Resistance, Microbial
Electrophoresis, Polyacrylamide Gel
Enterococcus faecium
Enterococcus faecium - drug effects
Enterococcus faecium - genetics
Glycopeptides
Gram-Positive Bacteria - drug effects
Hydrolysis
Magnetic Resonance Spectroscopy
Vancomycin - pharmacology
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Summary:AA3-Carboxyeremomycin 2, obtained by selective hydrolysis of antibiotic eremomycin was used as a starting compound for the eremomycin chemical modifications at the asparagine side chain to be transformed into eremomycin AA3, AA7 bis-amides (3a-c). Bis-benzylamide 3b displayed an activity (8μg/ml) against an E. faecium VanA strain.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.319