New Types of Liposidomycins Produced by Streptomyces that Inhibit Bacterial Peptidoglycan Synthesis Structure Elucidation of Fatty Acid Components by Tandem Mass Spectrometry

The structures of the fatty acid components of various new liposidomycins were determined using tandem mass Spectrometry; the negative FAB/MS/MS/MS technique for liposidomycins with a 3-methylglutaric acid moiety and the negative FAB/MS/MS technique for liposidomycins without a 3-methylglutaric acid...

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Bibliographic Details
Published in:Journal of antibiotics 1999/03/25, Vol.52(3), pp.281-287
Main Authors: ESUMI, YASUAKI, SUZUKI, YOSHIKATSU, KIMURA, KEN-ICHI, YOSHIHAMA, MAKOTO, ICHIKAWA, TERUO, URAMOTO, MASAKAZU
Format: Article
Language:English
Subjects:
Aminoglycosides
Analysis
Anti-Bacterial Agents - chemistry
Biological and medical sciences
Fatty Acids - chemistry
General pharmacology
Medical sciences
Peptidoglycan - metabolism
Pharmacology. Drug treatments
Spectrometry, Mass, Fast Atom Bombardment
Streptomyces
Streptomyces - metabolism
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Summary:The structures of the fatty acid components of various new liposidomycins were determined using tandem mass Spectrometry; the negative FAB/MS/MS/MS technique for liposidomycins with a 3-methylglutaric acid moiety and the negative FAB/MS/MS technique for liposidomycins without a 3-methylglutaric acid moiey. This structural information was obtained by analysis of peaks due to charge-remote fragmentations for 3-hydroxycarboxylate anions or carboxylate anions which were generated from liposidomycin molecules in a mass spectrometer. The MS/MS/MS technique that can exclude the matrix-derived and/or interfering ions showed higher sensitivity than the MS/MS technique.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.281