The Role of Calcium Metabolism in Human Red Blood Cell Ageing: A Proposal

The mechanisms of recognition, trapping and destruction of senescent human erythrocytes are not completely understood. Here we discuss some evidences supporting the idea that red cell ageing is closely related to a progressive increase in intracellular ionic Ca. This in turn, is the determining fact...

Full description

Saved in:
Bibliographic Details
Published in:Blood cells, molecules, & diseases molecules, & diseases, 1999-02, Vol.25 (1), p.9-19
Main Authors: Romero, Pedro J., Romero, Eneida A.
Format: Article
Language:English
Subjects:
Calcium - metabolism
Cellular Senescence
Erythrocytes - metabolism
Erythrocytes - pathology
erythrocytes, ageing, intracellular Ca, K(Ca)channel, Ca pump proteolysis
Humans
Potassium Channels - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The mechanisms of recognition, trapping and destruction of senescent human erythrocytes are not completely understood. Here we discuss some evidences supporting the idea that red cell ageing is closely related to a progressive increase in intracellular ionic Ca. This in turn, is the determining factor of a series of events such as Ca pump proteolysis and opening of the Ca-dependent K channel, that finally lead to the removal of old cells by macrophages at spleen level.
ISSN:1079-9796
1096-0961
DOI:10.1006/bcmd.1999.0222