Glucolipsin A and B, Two New Glucokinase Activators Produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii

During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA esters (FAC), two novel compounds, glucolipsin A (1) and B (2) were isolated from the butanol extracts of Streptomyces purpurogeniscleroticus WC...

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Published in:Journal of antibiotics 1999/03/25, Vol.52(3), pp.245-255
Main Authors: QIAN-CUTRONE, JINGFANG, UEKI, T., HUANG, STELLA, MOOKHTIAR, KASIM A., EZEKIEL, REGINA, KALINOWSKI, STEVEN S., BROWN, KAREN S., GOLIK, JERZY, LOWE, SUSAN, PIRNIK, DOLORES M., HUGILL, ROBERT, VEITCH, JUDY A., KLOHR, STEVEN E., WHITNEY, JEFFREY L., MANLY, SUSAN P.
Format: Article
Language:English
Subjects:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Disaccharides - biosynthesis
Disaccharides - pharmacology
Enzyme Activation
Fermentation
Fundamental and applied biological sciences. Psychology
Glucokinase - metabolism
Hydrolysis
Magnetic Resonance Spectroscopy
Microbiology
Nocardia - metabolism
Nocardia vaccinii
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
Streptomyces - metabolism
Streptomyces purpurogeniscleroticus
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Summary:During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA esters (FAC), two novel compounds, glucolipsin A (1) and B (2) were isolated from the butanol extracts of Streptomyces purpurogeniscleroticus WC71634 and Nocardia vaccinii WC65712, respectively. The structures of these two compounds were established by spectroscopic methods and chemical degradation. Glucolipsin A (1) and B (2) relieved the inhibition of glueokinase by FAC with RC50 values of 5.4 and 4.6μM.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.245