Novel Naphthoquinones from a Streptomyces sp

Cdc25A assay-guided fractionation of a fermentation broth derived from a Streptomyces sp. resulted in the isolation of four novel naphthoquinones 1-4. Structures of these compounds were deduced by NMR and mass spectrometry. Two of them, 3 and 4, incorporate a modified cysteine residue which is obser...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1999/03/25, Vol.52(3), pp.256-262
Main Authors: KULANTHAIVEL, PALANIAPPAN, PERUN, THOMAS J., BELVO, MATTHEW D., STROBEL, ROBERT J., PAUL, DONALD C., WILLIAMS, DANIEL C.
Format: Article
Language:English
Subjects:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
cdc25 Phosphatases
Chemotherapic agents
Chromatography, High Pressure Liquid
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Fermentation
Fundamental and applied biological sciences. Psychology
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
Microbiology
Naphthoquinones - isolation & purification
Naphthoquinones - pharmacology
Protein Tyrosine Phosphatases - antagonists & inhibitors
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
Streptomyces
Streptomyces - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cdc25A assay-guided fractionation of a fermentation broth derived from a Streptomyces sp. resulted in the isolation of four novel naphthoquinones 1-4. Structures of these compounds were deduced by NMR and mass spectrometry. Two of them, 3 and 4, incorporate a modified cysteine residue which is observed for the first time in this class of natural products. Naphthoquinones 1-4 showed weak activity against cdc25A phosphatase.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.256