Protein dynamical transition does not require protein structure

Terahertz time domain spectroscopy shows that the protein dynamical transition, the rapid increase in protein dynamics occurring at approximately 200 K, needs neither tertiary nor secondary structure. Further, short chain alanine studies find a dynamical transition down to penta-alanine, with no tra...

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Bibliographic Details
Published in:Physical review letters 2008-10, Vol.101 (17), p.178103-178103, Article 178103
Main Authors: He, Yunfen, Ku, Pei I, Knab, J R, Chen, J Y, Markelz, A G
Format: Article
Language:English
Subjects:
Computer Simulation
Egg Proteins - chemistry
Muramidase - chemistry
Peptides - chemistry
Polylysine - chemistry
Protein Denaturation
Protein Structure, Secondary
Spectrum Analysis - methods
Structure-Activity Relationship
Thermodynamics
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Summary:Terahertz time domain spectroscopy shows that the protein dynamical transition, the rapid increase in protein dynamics occurring at approximately 200 K, needs neither tertiary nor secondary structure. Further, short chain alanine studies find a dynamical transition down to penta-alanine, with no transition observed for di-alanine or tri-alanine. These results reveal the temperature dependence arises strictly from the side-chain interaction with the solvent. The lack of a transition for shorter chain peptides may indicate a qualitative change in this interaction occurs at a specific peptide chain length.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.101.178103