Polymeric Gadolinium Chelate Magnetic Resonance Imaging Contrast Agents:  Design, Synthesis, and Properties

We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physical properties including molecular weight, relaxivity, metal content, viscosity, and chelate stability c...

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Bibliographic Details
Published in:Bioconjugate chemistry 1999-05, Vol.10 (3), p.361-370
Main Authors: Ladd, David L, Hollister, Robert, Peng, Xin, Wei, Donna, Wu, Gang, Delecki, Daniel, Snow, Robert A, Toner, John L, Kellar, Kenneth, Eck, Jennifer, Desai, Vinay C, Raymond, Gemma, Kinter, Lewis B, Desser, Terry S, Rubin, Daniel L
Format: Article
Language:English
Subjects:
Animals
Chelating Agents - chemical synthesis
Chelating Agents - chemistry
Contrast Media - chemical synthesis
Contrast Media - chemistry
Drug Design
Feasibility Studies
Gadolinium - chemistry
Indicators and Reagents - chemistry
Magnetic Resonance Imaging - methods
Organometallic Compounds - chemistry
Polymers - chemistry
Rats
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Summary:We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physical properties including molecular weight, relaxivity, metal content, viscosity, and chelate stability could be varied. We have shown that, by selecting polymers of the appropriate MW, extended blood pool retention can be achieved. In addition, relaxivity can be manipulated by changing the polymer rigidity, metal content affected by monomer selection, viscosity by polymer shape, and chelate stability by chelator selection.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc980086+