Ionic Factors Governing Rebound Burst Phenotype in Rat Deep Cerebellar Neurons

Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada Submitted 1 April 2008; accepted in final form 27 August 2008 Large diameter cells in rat deep cerebellar nuclei (DCN) can be distinguished according to the generation of a transient or weak rebound burst and the expression o...

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Bibliographic Details
Published in:Journal of neurophysiology 2008-11, Vol.100 (5), p.2684-2701
Main Authors: Molineux, Michael L, Mehaffey, W. Hamish, Tadayonnejad, Reza, Anderson, Dustin, Tennent, Adrien F, Turner, Ray W
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Action Potentials - radiation effects
Animals
Animals, Newborn
Cadmium - pharmacology
Calcium - metabolism
Calcium Channels - physiology
Cerebellum - cytology
Electric Stimulation - methods
In Vitro Techniques
Ion Channel Gating - drug effects
Ion Channel Gating - physiology
Ion Channel Gating - radiation effects
Microtubule-Associated Proteins - metabolism
Neurons - classification
Neurons - drug effects
Neurons - physiology
Nickel - pharmacology
Patch-Clamp Techniques - methods
Phenotype
Potassium Channel Blockers - pharmacology
Potassium Channels - physiology
Rats
Rats, Sprague-Dawley
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Summary:Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada Submitted 1 April 2008; accepted in final form 27 August 2008 Large diameter cells in rat deep cerebellar nuclei (DCN) can be distinguished according to the generation of a transient or weak rebound burst and the expression of T-type Ca 2+ channel isoforms. We studied the ionic basis for the distinction in burst phenotypes in rat DCN cells in vitro. Following a hyperpolarization, transient burst cells generated a high-frequency spike burst of 450 Hz, whereas weak burst cells generated a lower-frequency increase (
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.90427.2008