A Cyclitol Derivative as a Replication Inhibitor from the Marine Sponge Petrosia sp

A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation....

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-05, Vol.62 (5), p.773-776
Main Authors: Kim, Dong-Kyoo, Lim, Young Ja, Kim, Jung Sun, Park, Jong Hee, Kim, Nam Deuk, Im, Kwang Sik, Hong, Jongki, Jung, Jee H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
cyclitol derivatives
DNA Replication - drug effects
DNA, Viral - metabolism
General pharmacology
Glycerol - analogs & derivatives
Glycerol - chemistry
Glycerol - isolation & purification
Glycerol - pharmacology
Magnetic Resonance Spectroscopy
Marine
Medical sciences
natural products
Nucleic Acid Synthesis Inhibitors - chemical synthesis
Nucleic Acid Synthesis Inhibitors - chemistry
Nucleic Acid Synthesis Inhibitors - pharmacology
Petrosia
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Simian virus 40 - metabolism
Spectrometry, Mass, Fast Atom Bombardment
Sugar Alcohols - chemistry
Sugar Alcohols - isolation & purification
Sugar Alcohols - pharmacology
Topoisomerase I Inhibitors
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Summary:A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9804785