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A Cyclitol Derivative as a Replication Inhibitor from the Marine Sponge Petrosia sp

A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation....

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 1999-05, Vol.62 (5), p.773-776
Main Authors:	Kim, Dong-Kyoo, Lim, Young Ja, Kim, Jung Sun, Park, Jong Hee, Kim, Nam Deuk, Im, Kwang Sik, Hong, Jongki, Jung, Jee H
Format:	Article
Language:	English
Subjects:	Animals Biological and medical sciences cyclitol derivatives DNA Replication - drug effects DNA, Viral - metabolism General pharmacology Glycerol - analogs & derivatives Glycerol - chemistry Glycerol - isolation & purification Glycerol - pharmacology Magnetic Resonance Spectroscopy Marine Medical sciences natural products Nucleic Acid Synthesis Inhibitors - chemical synthesis Nucleic Acid Synthesis Inhibitors - chemistry Nucleic Acid Synthesis Inhibitors - pharmacology Petrosia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Simian virus 40 - metabolism Spectrometry, Mass, Fast Atom Bombardment Sugar Alcohols - chemistry Sugar Alcohols - isolation & purification Sugar Alcohols - pharmacology Topoisomerase I Inhibitors
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creator	Kim, Dong-Kyoo Lim, Young Ja Kim, Jung Sun Park, Jong Hee Kim, Nam Deuk Im, Kwang Sik Hong, Jongki Jung, Jee H
description	A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.
doi_str_mv	10.1021/np9804785
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The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np9804785</identifier><identifier>PMID: 10346968</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Biological and medical sciences ; cyclitol derivatives ; DNA Replication - drug effects ; DNA, Viral - metabolism ; General pharmacology ; Glycerol - analogs & derivatives ; Glycerol - chemistry ; Glycerol - isolation & purification ; Glycerol - pharmacology ; Magnetic Resonance Spectroscopy ; Marine ; Medical sciences ; natural products ; Nucleic Acid Synthesis Inhibitors - chemical synthesis ; Nucleic Acid Synthesis Inhibitors - chemistry ; Nucleic Acid Synthesis Inhibitors - pharmacology ; Petrosia ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Porifera - chemistry ; Simian virus 40 - metabolism ; Spectrometry, Mass, Fast Atom Bombardment ; Sugar Alcohols - chemistry ; Sugar Alcohols - isolation & purification ; Sugar Alcohols - pharmacology ; Topoisomerase I Inhibitors</subject><ispartof>Journal of natural products (Washington, D.C.), 1999-05, Vol.62 (5), p.773-776</ispartof><rights>Copyright © 1999 American Chemical Society and American Society of Pharmacognosy</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a475t-b17ece52ad8b6a3eca1d1a4e6a8b111b488efde2b7709b6a8fa07fe77c34156a3</citedby><cites>FETCH-LOGICAL-a475t-b17ece52ad8b6a3eca1d1a4e6a8b111b488efde2b7709b6a8fa07fe77c34156a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1856564$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10346968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Dong-Kyoo</creatorcontrib><creatorcontrib>Lim, Young Ja</creatorcontrib><creatorcontrib>Kim, Jung Sun</creatorcontrib><creatorcontrib>Park, Jong Hee</creatorcontrib><creatorcontrib>Kim, Nam Deuk</creatorcontrib><creatorcontrib>Im, Kwang Sik</creatorcontrib><creatorcontrib>Hong, Jongki</creatorcontrib><creatorcontrib>Jung, Jee H</creatorcontrib><title>A Cyclitol Derivative as a Replication Inhibitor from the Marine Sponge Petrosia sp</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cyclitol derivatives</subject><subject>DNA Replication - drug effects</subject><subject>DNA, Viral - metabolism</subject><subject>General pharmacology</subject><subject>Glycerol - analogs & derivatives</subject><subject>Glycerol - chemistry</subject><subject>Glycerol - isolation & purification</subject><subject>Glycerol - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Marine</subject><subject>Medical sciences</subject><subject>natural products</subject><subject>Nucleic Acid Synthesis Inhibitors - chemical synthesis</subject><subject>Nucleic Acid Synthesis Inhibitors - chemistry</subject><subject>Nucleic Acid Synthesis Inhibitors - pharmacology</subject><subject>Petrosia</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Porifera - chemistry</subject><subject>Simian virus 40 - metabolism</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Sugar Alcohols - chemistry</subject><subject>Sugar Alcohols - isolation & purification</subject><subject>Sugar Alcohols - pharmacology</subject><subject>Topoisomerase I Inhibitors</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqF0E1P3DAQBmCrApUFeugfqHxokTik2Im_cmS3fEkgaJeerYl3AqbZJNhZBP--RlkBByROlsbPjGZeQr5y9pOznB-0fWmY0EZ-IhMuc5YplssNMmFcFVlhlNgi2zHeMcYKVsrPZIuzQqhSmQmZH9LZk2v80DX0Fwb_AIN_QAqRAv2DfeNdKnQtPWtvfZVUoHXolnS4RXoBwbdI533X3iC9wiF00QON_S7ZrKGJ-GX97pC_x0fXs9Ps_PLkbHZ4noHQcsgqrtGhzGFhKgUFOuALDgIVmIpzXgljsF5gXmnNyiRMDUzXqLUrBJepY4fsjXP70N2vMA526aPDpoEWu1W0qtQlF4Z9CLkWQgpRJrg_QpduiQFr2we_hPBkObPPUduXqJP9th66qpa4eCPHbBP4vgYQHTR1gNb5-OqMVFKJxLKR-Tjg48s3hH9W6UJLe301t_OpnJa_tbHT5H-MHly0d90qtCnjd_b7D2C9oHw</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>Kim, Dong-Kyoo</creator><creator>Lim, Young Ja</creator><creator>Kim, Jung Sun</creator><creator>Park, Jong Hee</creator><creator>Kim, Nam Deuk</creator><creator>Im, Kwang Sik</creator><creator>Hong, Jongki</creator><creator>Jung, Jee H</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990501</creationdate><title>A Cyclitol Derivative as a Replication Inhibitor from the Marine Sponge Petrosia sp</title><author>Kim, Dong-Kyoo ; Lim, Young Ja ; Kim, Jung Sun ; Park, Jong Hee ; Kim, Nam Deuk ; Im, Kwang Sik ; Hong, Jongki ; Jung, Jee H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a475t-b17ece52ad8b6a3eca1d1a4e6a8b111b488efde2b7709b6a8fa07fe77c34156a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cyclitol derivatives</topic><topic>DNA Replication - drug effects</topic><topic>DNA, Viral - metabolism</topic><topic>General pharmacology</topic><topic>Glycerol - analogs & derivatives</topic><topic>Glycerol - chemistry</topic><topic>Glycerol - isolation & purification</topic><topic>Glycerol - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Marine</topic><topic>Medical sciences</topic><topic>natural products</topic><topic>Nucleic Acid Synthesis Inhibitors - chemical synthesis</topic><topic>Nucleic Acid Synthesis Inhibitors - chemistry</topic><topic>Nucleic Acid Synthesis Inhibitors - pharmacology</topic><topic>Petrosia</topic><topic>Pharmacognosy. 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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Animals Biological and medical sciences cyclitol derivatives DNA Replication - drug effects DNA, Viral - metabolism General pharmacology Glycerol - analogs & derivatives Glycerol - chemistry Glycerol - isolation & purification Glycerol - pharmacology Magnetic Resonance Spectroscopy Marine Medical sciences natural products Nucleic Acid Synthesis Inhibitors - chemical synthesis Nucleic Acid Synthesis Inhibitors - chemistry Nucleic Acid Synthesis Inhibitors - pharmacology Petrosia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Simian virus 40 - metabolism Spectrometry, Mass, Fast Atom Bombardment Sugar Alcohols - chemistry Sugar Alcohols - isolation & purification Sugar Alcohols - pharmacology Topoisomerase I Inhibitors
title	A Cyclitol Derivative as a Replication Inhibitor from the Marine Sponge Petrosia sp
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