Comparative in-vitro activities of moxifloxacin, trovafloxacin, quinupristin/dalfopristin and linezolid against staphylococci

The antistaphylococcal activities of four newly developed antibiotics, moxifloxacin (an 8-methoxyfluoroquinolone), trovafloxacin (a naphthyridone), quinupristin/dalfopristin (a semisynthetic streptogramin) and linezolid (an oxazolidinone), were examined and compared with those of ciprofloxacin, vanc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1999-04, Vol.43 (4), p.569-573
Main Authors: VON EIFF, C, PETERS, G
Format: Article
Language:English
Subjects:
Acetamides - pharmacology
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Aza Compounds
Biological and medical sciences
Fluoroquinolones
Humans
Linezolid
Medical sciences
Methicillin Resistance
Microbial Sensitivity Tests
Moxifloxacin
Naphthyridines - pharmacology
Oxazoles - pharmacology
Oxazolidinones
Pharmacology. Drug treatments
Quinolines
Staphylococcal Infections - microbiology
Staphylococcus
Staphylococcus - drug effects
Staphylococcus - isolation & purification
Virginiamycin - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The antistaphylococcal activities of four newly developed antibiotics, moxifloxacin (an 8-methoxyfluoroquinolone), trovafloxacin (a naphthyridone), quinupristin/dalfopristin (a semisynthetic streptogramin) and linezolid (an oxazolidinone), were examined and compared with those of ciprofloxacin, vancomycin and teicoplanin, using an agar dilution method. A total of 245 clinical isolates of staphylococci, including a large number of clonally different methicillin-resistant strains, were tested. The new agents tested exhibited wide-spectrum antistaphylococcal activity against both methicillin-susceptible and methicillin-resistant strains. In contrast to the quinolones, the in-vitro activities of quinupristin/dalfopristin, linezolid and the glycopeptides remained almost unchanged, irrespective of the resistance phenotype for methicillin. A number of isolates with elevated quinolone MICs were observed.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/43.4.569