Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects

Annexin A1 (ANXA1, formerly termed lipocortin 1 or macrocortin) is an important protein mediator of the feedback actions of glucocorticoids within the hypothalamo-pituitary-adrenocortical (HPA) axis. Here we consider the mechanisms by which ANXA1 exerts these actions, with particular reference to th...

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Bibliographic Details
Published in:Current opinion in pharmacology 2008-12, Vol.8 (6), p.765-776
Main Authors: John, Christopher D, Gavins, Felicity NE, Buss, Nicholas APS, Cover, Patricia O, Buckingham, Julia C
Format: Article
Language:English
Subjects:
Animals
Annexin A1 - metabolism
Annexin A1 - physiology
Glucocorticoids - metabolism
Glucocorticoids - physiology
Humans
Hypothalamo-Hypophyseal System - physiology
Internal Medicine
Medical Education
Models, Biological
Pituitary-Adrenal System - physiology
Receptors, Formyl Peptide - metabolism
Receptors, Formyl Peptide - physiology
Signal Transduction - physiology
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Summary:Annexin A1 (ANXA1, formerly termed lipocortin 1 or macrocortin) is an important protein mediator of the feedback actions of glucocorticoids within the hypothalamo-pituitary-adrenocortical (HPA) axis. Here we consider the mechanisms by which ANXA1 exerts these actions, with particular reference to the potential role of the formyl peptide receptors (FPRs), a family of G-protein-coupled receptors which has only very recently been implicated in the regulation of neuroendocrine function. In addition, we discuss evidence that ANXA1 contributes to the regulation of other aspects of endocrine and metabolic function and to the aetiology of sexual dimorphisms.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2008.09.005