Correlation between genotype and β-lactamases of clinical and environmental strains of Stenotrophomonas maltophilia

Heterogeneity of beta-lactamase production by 17 clinical and nine environmental isolates of Stenotrophomonas maltophilia was investigated using MICs of six different beta-lactam antibiotics, isoelectric focusing (IEF) and pulsed field gel electrophoresis. There was no clear correlation between the...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1999-04, Vol.43 (4), p.555-558
Main Authors: DENTON, M, KEER, V, HAWKEY, P. M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactamases - chemistry
beta-Lactamases - genetics
beta-Lactams
Biological and medical sciences
Cystic Fibrosis - microbiology
Electrophoresis, Gel, Pulsed-Field
Gram-Negative Bacterial Infections - microbiology
Humans
Isoelectric Focusing
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Sputum - microbiology
Stenotrophomonas maltophilia
Xanthomonas - drug effects
Xanthomonas - enzymology
Xanthomonas - genetics
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Summary:Heterogeneity of beta-lactamase production by 17 clinical and nine environmental isolates of Stenotrophomonas maltophilia was investigated using MICs of six different beta-lactam antibiotics, isoelectric focusing (IEF) and pulsed field gel electrophoresis. There was no clear correlation between the results of IEF, genotype and MIC determination. Environmental isolates were more susceptible than clinical isolates; eight clinical and none of the environmental isolates expressed high-level resistance to meropenem. Only two isolates expressed high-level resistance to ceftazidime. These results indicate that further studies are required to elucidate the extent of genetic heterogeneity within the L1 and L2 beta-lactamase genes.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/43.4.555