Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha

Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis....

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Bibliographic Details
Published in:FEBS letters 2008-11, Vol.582 (28), p.3884-3888
Main Authors: Tachibana, Keisuke, Anzai, Naohiko, Ueda, Chihiro, Katayama, Tatsuya, Yamasaki, Daisuke, Kirino, Takayoshi, Takahashi, Rika, Ishimoto, Kenji, Komori, Hidenori, Tanaka, Toshiya, Hamakubo, Takao, Ueda, Yukihiko, Arai, Hiroyuki, Sakai, Juro, Kodama, Tatsuhiko, Doi, Takefumi
Format: Article
Language:English
Subjects:
5' Flanking Region
Base Sequence
Carrier Proteins - genetics
Cell Line
Humans
Molecular Sequence Data
PDZK1
peroxisome proliferator responsive element
peroxisome proliferator-activated receptor
PPAR
PPAR alpha - metabolism
PPARα
PPRE
Promoter Regions, Genetic - drug effects
retinoid X receptor
RXR
Target gene
Tetracycline - pharmacology
Transcription Initiation Site
Transcription, Genetic
Transcriptional Activation
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Summary:Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis. Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARα and identified candidate target genes, one of which was PDZK1. In this study, we cloned and characterized the promoter region of the human pdzk1 gene and determined the PPAR response element. Finally, we demonstrate that endogenous PPARα regulates PDZK1 expression.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2008.10.027