Loading…
Hypothyroxinemia of prematurity and the risk of cerebral white matter damage
Objective: Infants with hypothyroxinemia of prematurity (HOP) are at increased risk for neurodevelopmental dysfunction. Infants born near the end of the middle trimester are also at increased risk for an echolucency (EL) in the cerebral white matter, which reflects white matter damage and is the cra...
Saved in:
| Published in: | The Journal of pediatrics 1999-06, Vol.134 (6), p.706-711 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c437t-a1376798580be4d57ec491caf7118bad57b2c28497af42a6f64a606dd1e1e5f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c437t-a1376798580be4d57ec491caf7118bad57b2c28497af42a6f64a606dd1e1e5f3 |
| container_end_page | 711 |
| container_issue | 6 |
| container_start_page | 706 |
| container_title | The Journal of pediatrics |
| container_volume | 134 |
| creator | Leviton, Alan Paneth, Nigel Reuss, M.Lynne Susser, Mervyn Allred, Elizabeth N. Dammann, Olaf Kuban, Karl Van Marter, Linda J. Pagano, Marcello |
| description | Objective: Infants with hypothyroxinemia of prematurity (HOP) are at increased risk for neurodevelopmental dysfunction. Infants born near the end of the middle trimester are also at increased risk for an echolucency (EL) in the cerebral white matter, which reflects white matter damage and is the cranial ultrasound abnormality that best predicts neurodevelopmental dysfunction. We postulated that some of the increased risk of neurodevelopmental problems associated with HOP reflects an increased risk of EL.
Study design: We studied 1414 infants weighing 500 to 1500 g who were born at 4 medical centers between 1991 and 1993. The infants had thyroxine blood levels measured during the first weeks of life, at least 1 of 3 cranial ultrasound scans performed at specified postnatal intervals, and their own and their mother’s hospital charts reviewed. Infants were classified by whether or not their first thyroxine level placed them in the lowest quartile among all infants in this sample (ie, |
| doi_str_mv | 10.1016/S0022-3476(99)70285-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69796775</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347699702854</els_id><sourcerecordid>69796775</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-a1376798580be4d57ec491caf7118bad57b2c28497af42a6f64a606dd1e1e5f3</originalsourceid><addsrcrecordid>eNqF0MtKxDAUgOEgio6XR1C6ENFFNWnTXFYigzcYcKH7cJqeOtFexiSjztvbcQZ15yqQfCcJPyGHjJ4zysTFI6VZluZcilOtzyTNVJHyDTJiVMtUqDzfJKMfskN2Q3ihlGpO6TbZYTQvBMvViEzuFrM-The-_3Qdtg6Svk5mHluIc-_iIoGuSuIUE-_C6_LMosfSQ5N8TF3EZHARfVJBC8-4T7ZqaAIerNc98nRz_TS-SycPt_fjq0lqeS5jCiyXQmpVKFoirwqJlmtmoZaMqRKGjTKzmeJaQs0zELXgIKioKoYMizrfIyera2e-f5tjiKZ1wWLTQIf9PBihpRZSFgMsVtD6PgSPtZl514JfGEbNsqL5rmiWiYzW5rui4cPc0fqBedli9WdqlW0Ax2sAwUJTe-isC79OccULNrDLFcMhxrtDb4J12FmsnEcbTdW7f37yBVcHjsY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69796775</pqid></control><display><type>article</type><title>Hypothyroxinemia of prematurity and the risk of cerebral white matter damage</title><source>Elsevier</source><creator>Leviton, Alan ; Paneth, Nigel ; Reuss, M.Lynne ; Susser, Mervyn ; Allred, Elizabeth N. ; Dammann, Olaf ; Kuban, Karl ; Van Marter, Linda J. ; Pagano, Marcello</creator><creatorcontrib>Leviton, Alan ; Paneth, Nigel ; Reuss, M.Lynne ; Susser, Mervyn ; Allred, Elizabeth N. ; Dammann, Olaf ; Kuban, Karl ; Van Marter, Linda J. ; Pagano, Marcello ; for The Developmental Epidemiology Network Investigators</creatorcontrib><description>Objective: Infants with hypothyroxinemia of prematurity (HOP) are at increased risk for neurodevelopmental dysfunction. Infants born near the end of the middle trimester are also at increased risk for an echolucency (EL) in the cerebral white matter, which reflects white matter damage and is the cranial ultrasound abnormality that best predicts neurodevelopmental dysfunction. We postulated that some of the increased risk of neurodevelopmental problems associated with HOP reflects an increased risk of EL.
Study design: We studied 1414 infants weighing 500 to 1500 g who were born at 4 medical centers between 1991 and 1993. The infants had thyroxine blood levels measured during the first weeks of life, at least 1 of 3 cranial ultrasound scans performed at specified postnatal intervals, and their own and their mother’s hospital charts reviewed. Infants were classified by whether or not their first thyroxine level placed them in the lowest quartile among all infants in this sample (ie, <67.8 nmol/L, our definition of HOP, equivalent to <5.3 μg/dL).
Results: After adjusting for such potential confounders as low gestational age and measures of illness severity, infants with HOP had twice the risk of EL as their peers with higher thyroxine levels.
Conclusion: Our findings are consistent with the hypothesis that a “normal” blood thyroxine level protects infants born near the end of the middle trimester against the risk of cerebral white matter damage. (J Pediatr 1999;134:706-11)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(99)70285-4</identifier><identifier>PMID: 10356138</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Brain - embryology ; Brain - growth & development ; Brain - pathology ; Echoencephalography ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature - blood ; Infant, Very Low Birth Weight ; Intensive care medicine ; Medical sciences ; Odds Ratio ; Placenta - pathology ; Risk Factors ; Severity of Illness Index ; Thyroxine - blood ; Ultrasonography, Prenatal</subject><ispartof>The Journal of pediatrics, 1999-06, Vol.134 (6), p.706-711</ispartof><rights>1999 Mosby, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-a1376798580be4d57ec491caf7118bad57b2c28497af42a6f64a606dd1e1e5f3</citedby><cites>FETCH-LOGICAL-c437t-a1376798580be4d57ec491caf7118bad57b2c28497af42a6f64a606dd1e1e5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1848451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10356138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leviton, Alan</creatorcontrib><creatorcontrib>Paneth, Nigel</creatorcontrib><creatorcontrib>Reuss, M.Lynne</creatorcontrib><creatorcontrib>Susser, Mervyn</creatorcontrib><creatorcontrib>Allred, Elizabeth N.</creatorcontrib><creatorcontrib>Dammann, Olaf</creatorcontrib><creatorcontrib>Kuban, Karl</creatorcontrib><creatorcontrib>Van Marter, Linda J.</creatorcontrib><creatorcontrib>Pagano, Marcello</creatorcontrib><creatorcontrib>for The Developmental Epidemiology Network Investigators</creatorcontrib><title>Hypothyroxinemia of prematurity and the risk of cerebral white matter damage</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective: Infants with hypothyroxinemia of prematurity (HOP) are at increased risk for neurodevelopmental dysfunction. Infants born near the end of the middle trimester are also at increased risk for an echolucency (EL) in the cerebral white matter, which reflects white matter damage and is the cranial ultrasound abnormality that best predicts neurodevelopmental dysfunction. We postulated that some of the increased risk of neurodevelopmental problems associated with HOP reflects an increased risk of EL.
Study design: We studied 1414 infants weighing 500 to 1500 g who were born at 4 medical centers between 1991 and 1993. The infants had thyroxine blood levels measured during the first weeks of life, at least 1 of 3 cranial ultrasound scans performed at specified postnatal intervals, and their own and their mother’s hospital charts reviewed. Infants were classified by whether or not their first thyroxine level placed them in the lowest quartile among all infants in this sample (ie, <67.8 nmol/L, our definition of HOP, equivalent to <5.3 μg/dL).
Results: After adjusting for such potential confounders as low gestational age and measures of illness severity, infants with HOP had twice the risk of EL as their peers with higher thyroxine levels.
Conclusion: Our findings are consistent with the hypothesis that a “normal” blood thyroxine level protects infants born near the end of the middle trimester against the risk of cerebral white matter damage. (J Pediatr 1999;134:706-11)</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Brain - embryology</subject><subject>Brain - growth & development</subject><subject>Brain - pathology</subject><subject>Echoencephalography</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Infant, Very Low Birth Weight</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Placenta - pathology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Thyroxine - blood</subject><subject>Ultrasonography, Prenatal</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqF0MtKxDAUgOEgio6XR1C6ENFFNWnTXFYigzcYcKH7cJqeOtFexiSjztvbcQZ15yqQfCcJPyGHjJ4zysTFI6VZluZcilOtzyTNVJHyDTJiVMtUqDzfJKMfskN2Q3ihlGpO6TbZYTQvBMvViEzuFrM-The-_3Qdtg6Svk5mHluIc-_iIoGuSuIUE-_C6_LMosfSQ5N8TF3EZHARfVJBC8-4T7ZqaAIerNc98nRz_TS-SycPt_fjq0lqeS5jCiyXQmpVKFoirwqJlmtmoZaMqRKGjTKzmeJaQs0zELXgIKioKoYMizrfIyera2e-f5tjiKZ1wWLTQIf9PBihpRZSFgMsVtD6PgSPtZl514JfGEbNsqL5rmiWiYzW5rui4cPc0fqBedli9WdqlW0Ax2sAwUJTe-isC79OccULNrDLFcMhxrtDb4J12FmsnEcbTdW7f37yBVcHjsY</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Leviton, Alan</creator><creator>Paneth, Nigel</creator><creator>Reuss, M.Lynne</creator><creator>Susser, Mervyn</creator><creator>Allred, Elizabeth N.</creator><creator>Dammann, Olaf</creator><creator>Kuban, Karl</creator><creator>Van Marter, Linda J.</creator><creator>Pagano, Marcello</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Hypothyroxinemia of prematurity and the risk of cerebral white matter damage</title><author>Leviton, Alan ; Paneth, Nigel ; Reuss, M.Lynne ; Susser, Mervyn ; Allred, Elizabeth N. ; Dammann, Olaf ; Kuban, Karl ; Van Marter, Linda J. ; Pagano, Marcello</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-a1376798580be4d57ec491caf7118bad57b2c28497af42a6f64a606dd1e1e5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Brain - embryology</topic><topic>Brain - growth & development</topic><topic>Brain - pathology</topic><topic>Echoencephalography</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Infant, Very Low Birth Weight</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Placenta - pathology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Thyroxine - blood</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leviton, Alan</creatorcontrib><creatorcontrib>Paneth, Nigel</creatorcontrib><creatorcontrib>Reuss, M.Lynne</creatorcontrib><creatorcontrib>Susser, Mervyn</creatorcontrib><creatorcontrib>Allred, Elizabeth N.</creatorcontrib><creatorcontrib>Dammann, Olaf</creatorcontrib><creatorcontrib>Kuban, Karl</creatorcontrib><creatorcontrib>Van Marter, Linda J.</creatorcontrib><creatorcontrib>Pagano, Marcello</creatorcontrib><creatorcontrib>for The Developmental Epidemiology Network Investigators</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leviton, Alan</au><au>Paneth, Nigel</au><au>Reuss, M.Lynne</au><au>Susser, Mervyn</au><au>Allred, Elizabeth N.</au><au>Dammann, Olaf</au><au>Kuban, Karl</au><au>Van Marter, Linda J.</au><au>Pagano, Marcello</au><aucorp>for The Developmental Epidemiology Network Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothyroxinemia of prematurity and the risk of cerebral white matter damage</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>134</volume><issue>6</issue><spage>706</spage><epage>711</epage><pages>706-711</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective: Infants with hypothyroxinemia of prematurity (HOP) are at increased risk for neurodevelopmental dysfunction. Infants born near the end of the middle trimester are also at increased risk for an echolucency (EL) in the cerebral white matter, which reflects white matter damage and is the cranial ultrasound abnormality that best predicts neurodevelopmental dysfunction. We postulated that some of the increased risk of neurodevelopmental problems associated with HOP reflects an increased risk of EL.
Study design: We studied 1414 infants weighing 500 to 1500 g who were born at 4 medical centers between 1991 and 1993. The infants had thyroxine blood levels measured during the first weeks of life, at least 1 of 3 cranial ultrasound scans performed at specified postnatal intervals, and their own and their mother’s hospital charts reviewed. Infants were classified by whether or not their first thyroxine level placed them in the lowest quartile among all infants in this sample (ie, <67.8 nmol/L, our definition of HOP, equivalent to <5.3 μg/dL).
Results: After adjusting for such potential confounders as low gestational age and measures of illness severity, infants with HOP had twice the risk of EL as their peers with higher thyroxine levels.
Conclusion: Our findings are consistent with the hypothesis that a “normal” blood thyroxine level protects infants born near the end of the middle trimester against the risk of cerebral white matter damage. (J Pediatr 1999;134:706-11)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>10356138</pmid><doi>10.1016/S0022-3476(99)70285-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1999-06, Vol.134 (6), p.706-711 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69796775 |
| source | Elsevier |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Brain - embryology Brain - growth & development Brain - pathology Echoencephalography Emergency and intensive care: neonates and children. Prematurity. Sudden death Gestational Age Humans Infant, Newborn Infant, Premature - blood Infant, Very Low Birth Weight Intensive care medicine Medical sciences Odds Ratio Placenta - pathology Risk Factors Severity of Illness Index Thyroxine - blood Ultrasonography, Prenatal |
| title | Hypothyroxinemia of prematurity and the risk of cerebral white matter damage |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A04%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypothyroxinemia%20of%20prematurity%20and%20the%20risk%20of%20cerebral%20white%20matter%20damage&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Leviton,%20Alan&rft.aucorp=for%20The%20Developmental%20Epidemiology%20Network%20Investigators&rft.date=1999-06-01&rft.volume=134&rft.issue=6&rft.spage=706&rft.epage=711&rft.pages=706-711&rft.issn=0022-3476&rft.eissn=1097-6833&rft.coden=JOPDAB&rft_id=info:doi/10.1016/S0022-3476(99)70285-4&rft_dat=%3Cproquest_cross%3E69796775%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c437t-a1376798580be4d57ec491caf7118bad57b2c28497af42a6f64a606dd1e1e5f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69796775&rft_id=info:pmid/10356138&rfr_iscdi=true |