Measurement of suprathreshold binocular interactions in amblyopia

It has been established that in amblyopia, information from the amblyopic eye (AME) is not combined with that from the fellow fixing eye (FFE) under conditions of binocular viewing. However, recent evidence suggests that mechanisms that combine information between the eyes are intact in amblyopia. T...

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Bibliographic Details
Published in:Vision research (Oxford) 2008-12, Vol.48 (28), p.2775-2784
Main Authors: Mansouri, B., Thompson, B., Hess, R.F.
Format: Article
Language:English
Subjects:
Accommodation, Ocular - physiology
Adult
Amblyopia
Amblyopia - physiopathology
Binocular summation
Biological and medical sciences
Contrast
Dichoptic interaction
Discrimination (Psychology)
Eye and associated structures. Visual pathways and centers. Vision
Female
Form Perception - physiology
Fundamental and applied biological sciences. Psychology
Global form perception
Global motion
Global motion perception
Humans
Male
Medical sciences
Middle Aged
Motion Perception - physiology
Ophthalmology
Psychophysics
Sensory Thresholds
Treatment of amblyopia
Vertebrates: nervous system and sense organs
Vision disorders
Vision, Binocular - physiology
Visual Perception - physiology
Young Adult
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Summary:It has been established that in amblyopia, information from the amblyopic eye (AME) is not combined with that from the fellow fixing eye (FFE) under conditions of binocular viewing. However, recent evidence suggests that mechanisms that combine information between the eyes are intact in amblyopia. The lack of binocular function is most likely due to the imbalanced inputs from the two eyes under binocular conditions [Baker, D. H., Meese, T. S., Mansouri, B., & Hess, R. F. (2007b). Binocular summation of contrast remains intact in strabismic amblyopia. Investigative Ophthalmology & Visual Science, 48(11), 5332–5338]. We have measured the extent to which the information presented to each eye needs to differ for binocular combination to occur and in doing so we quantify the influence of interocular suppression. We quantify these suppressive effects for suprathreshold processing of global stimuli for both motion and spatial tasks. The results confirm the general importance of these suppressive effects in rendering the structurally binocular visual system of a strabismic amblyope, functionally monocular.
ISSN:0042-6989
1878-5646
DOI:10.1016/j.visres.2008.09.002