Serotype-specificity of recombinant fusion proteins containing domain III of dengue virus

Here, the antigenic specificity of the recombinant fusion proteins containing aa 286–426 of the dengue envelope protein fused to P64k from Neisseria meningitidis and the cross-reactive antibody response induced in immunized mice and monkeys were evaluated. The anti-dengue mice antibodies showed a hi...

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Bibliographic Details
Published in:Virus research 2008-12, Vol.138 (1), p.135-138
Main Authors: Izquierdo, Alienys, Bernardo, Lidice, Martin, Jorge, Santana, Emidalys, Hermida, Lisset, Guillén, Gerardo, Guzmán, María G.
Format: Article
Language:English
Subjects:
Animals
Cercopithecus aethiops
Cross Reactions
Cross-reactivity
Dengue
Dengue - immunology
Dengue - virology
Dengue Vaccines - chemistry
Dengue Vaccines - immunology
Dengue virus
Dengue Virus - chemistry
Dengue Virus - immunology
Domain III
Epitopes - immunology
Humans
Macaca fascicularis
Mice
Mice, Inbred BALB C
Neisseria meningitidis
Neisseria meningitidis - immunology
P64k
Protein Structure, Tertiary
Recombinant Fusion Proteins - chemistry
Recombinant Fusion Proteins - immunology
Recombinant protein
Vaccine
Vero Cells
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Summary:Here, the antigenic specificity of the recombinant fusion proteins containing aa 286–426 of the dengue envelope protein fused to P64k from Neisseria meningitidis and the cross-reactive antibody response induced in immunized mice and monkeys were evaluated. The anti-dengue mice antibodies showed a higher reactivity to the homologous recombinant proteins compared to the wide cross-reactivity observed by dot blot to the viral antigens. The immune response induced by the recombinant proteins in mice and monkeys, was highly serotype specific. The serotype-specificity associated with these recombinant proteins in addition to the high antigenicity, immunogenicity and protecting capacity suggest their advantages as possible vaccine candidates.
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2008.08.008