Activities of Plant-Derived Phenols in a Fibroblast Cell Culture Model

Fourteen plant phenols of five structural groups (flavones, flavonols, flavan-3-ol, isoflavones, and phenylpropanoids) demonstrated concentration-dependent inhibitory or modulatory effects in a fibroblast cell culture model. The most potent inhibitory activity in this investigation was exhibited by...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-03, Vol.62 (3), p.481-483
Main Authors: Koganov, Michael M, Dueva, Olga V, Tsorin, Boris L
Format: Article
Language:English
Subjects:
Biological and medical sciences
cell growth
chemical structure
fibroblasts
flavones
flavonols
General pharmacology
inhibition
isoflavones
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phenylpropanoids
plant extracts
spectral analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fourteen plant phenols of five structural groups (flavones, flavonols, flavan-3-ol, isoflavones, and phenylpropanoids) demonstrated concentration-dependent inhibitory or modulatory effects in a fibroblast cell culture model. The most potent inhibitory activity in this investigation was exhibited by apigenin (4), with flavone (1), chrysin (2), and genistein (9) being of somewhat lesser potency. These findings help to provide a better understanding of the action of these plant phenols in inflammatory/immune responses.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9801559