Penicillin tolerance in Streptococcus pneumoniae, autolysis and the Psa ATP‐binding cassette (ABC) manganese permease

Recently, Novak et al. reported their investigation on the phenomenon of penicillin tolerance in Streptococcus pneumoniae. A library of mutants in pneumococcal surface proteins was screened for the ability to survive in the presence of 10x the minimum inhibitory concentration of antibiotic. A mutant...

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Bibliographic Details
Published in:Molecular microbiology 1999-05, Vol.32 (4), p.881-883
Main Authors: Claverys, Jean‐Pierre, Granadel, Chantal, Berry, Anne M., Paton, James C.
Format: Article
Language:English
Subjects:
ATP-Binding Cassette Transporters - genetics
Bacteriolysis - genetics
Deoxycholic Acid - pharmacology
Enzymes - genetics
Kinetics
Manganese - metabolism
Mutation
N-Acetylmuramoyl-L-alanine Amidase
Penicillin Resistance - genetics
Phenotype
Streptococcus pneumoniae
Streptococcus pneumoniae - genetics
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Summary:Recently, Novak et al. reported their investigation on the phenomenon of penicillin tolerance in Streptococcus pneumoniae. A library of mutants in pneumococcal surface proteins was screened for the ability to survive in the presence of 10x the minimum inhibitory concentration of antibiotic. A mutant harbouring an insertion in the known gene psaA was isolated among 10 candidate tolerance mutants. Inactivation of psaA was previously shown to result in reduced virulence of S. pneumoniae (as judged by intranasal or intraperitoneal challenge of mice) and in reduced adherence to A549 cells (type II pneumocytes), leading to the suggestion that PsaA was an adhesin. This gene is part of the psa locus that encodes an ATP-binding cassette (ABC) permease belonging to cluster 9, a family of ABC metal permeases.
ISSN:0950-382X
1365-2958
DOI:10.1046/j.1365-2958.1999.01369.x