Cholesterol-Lowering Properties of Whole Cowpea Seed and Its Protein Isolate in Hamsters

Hypercholesterolemic hamsters were fed for 4 wk on diets rich in saturated fatty acids and cholesterol, differing only in protein source (20 %): casein (control group, HC), whole cowpea seed (HWS), and cowpea protein isolate (HPI). Hamsters fed on HWS and HPI presented significant reductions in plas...

Full description

Saved in:
Bibliographic Details
Published in:Journal of food science 2008-11, Vol.73 (9), p.H235-H240
Main Authors: Frota, K.M.G, Mendonça, S, Saldiva, P.H.N, Cruz, R.J, Arêas, J.A.G
Format: Article
Language:English
Subjects:
animal disease models
Animals
Anticholesteremic Agents - pharmacology
bile acids
Bile Acids and Salts - metabolism
Biological and medical sciences
blood lipids
casein
cholesteremic effect
Cholesterol
Cholesterol, Dietary - metabolism
cowpea
cowpeas
Cricetinae
dietary fat
Dietary Fiber - pharmacology
digestible protein
Digestion
Energy Intake
Fabaceae
Fatty acids
fatty liver
feces
Food industries
Fundamental and applied biological sciences. Psychology
hamsters
Histology
hypercholesterolemia
Hypercholesterolemia - blood
Hypercholesterolemia - metabolism
hypocholesterolemia
lipid metabolism
Lipids - blood
Lipoproteins - blood
Liver
Male
Mesocricetus
Metabolism
Plant Proteins - pharmacology
protein isolate
protein isolates
Proteins
Rodents
saturated fatty acids
Seeds
steatosis
Triglycerides - blood
whole seeds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypercholesterolemic hamsters were fed for 4 wk on diets rich in saturated fatty acids and cholesterol, differing only in protein source (20 %): casein (control group, HC), whole cowpea seed (HWS), and cowpea protein isolate (HPI). Hamsters fed on HWS and HPI presented significant reductions in plasma total cholesterol and non-HDL cholesterol. HPI and HC presented similar protein digestibility, which were significantly higher than that of HWS. Animals fed on HWS presented significantly higher levels of bile acids and cholesterol in feces than did the animals fed on casein or HPI diets. Histological analyses of the liver showed that HC diet resulted in steatosis widely distributed throughout the hepatic lobule, while HWS and HPI diets promoted reductions in liver steatosis. The effectiveness of HWS for modulating lipid metabolism was greater than that of HPI, as measured by plasma cholesterol reduction and liver steatosis.
ISSN:0022-1147
1750-3841
DOI:10.1111/j.1750-3841.2008.00953.x