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Utility of Myocardial Fibrosis and Fatty Infiltration Detected by Cardiac Magnetic Resonance Imaging in the Diagnosis of Arrhythmogenic Right Ventricular Dysplasia—A Single Centre Experience
Introduction Cardiac magnetic resonance imaging (CMR) has evolved as a major diagnostic tool to evaluate arrhythmogenic right ventricular dysplasia (ARVD). However, there is a lack of consensus in the interpretation of findings such as fatty infiltration or myocardial fibrosis. We examined the diagn...
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Published in: | Heart, lung & circulation lung & circulation, 2008-12, Vol.17 (6), p.478-483 |
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description | Introduction Cardiac magnetic resonance imaging (CMR) has evolved as a major diagnostic tool to evaluate arrhythmogenic right ventricular dysplasia (ARVD). However, there is a lack of consensus in the interpretation of findings such as fatty infiltration or myocardial fibrosis. We examined the diagnostic utility of these two features in the diagnosis of ARVD. Methods We performed fast imaging employing steady-state acquisition cine imaging, T1 -weighted black blood imaging with and without fat suppression and post-contrast delayed enhancement on a 1.5-T scanner to evaluate ventricular function and morphology, fatty infiltration and regional myocardial fibrosis in 52 subjects with suspected ARVD. Results Eight subjects met the international diagnostic criteria for ARVD. Right ventricle (RV) delayed hyper-enhancement was found in 7 of 8 (88%) ARVD subjects compared to 6 of 44 (14%) subjects without ARVD ( p < 0.001). Fatty infiltration was only identified in 1 ARVD patient, and 1 non-ARVD patient. On multiple logistic regression analysis RV enhancement remained an independent predictor for the diagnosis of ARVD ( p < 0.05). Conclusion RV delayed enhancement is common in patients with ARVD, whereas detection of fatty infiltration of the right ventricle was rare in our patient population. The inclusion of RV fibrosis on CMR as a feature of ARVD may improve the diagnostic accuracy of this condition. |
doi_str_mv | 10.1016/j.hlc.2008.03.085 |
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AMIT ; Taylor, Andrew J., PhD</creator><creatorcontrib>Pfluger, Heinz B., MD ; Phrommintikul, Arintaya, MD ; Mariani, Justin A., FRACP ; Cherayath, Joshi G., Dip. AMIT ; Taylor, Andrew J., PhD</creatorcontrib><description>Introduction Cardiac magnetic resonance imaging (CMR) has evolved as a major diagnostic tool to evaluate arrhythmogenic right ventricular dysplasia (ARVD). However, there is a lack of consensus in the interpretation of findings such as fatty infiltration or myocardial fibrosis. We examined the diagnostic utility of these two features in the diagnosis of ARVD. Methods We performed fast imaging employing steady-state acquisition cine imaging, T1 -weighted black blood imaging with and without fat suppression and post-contrast delayed enhancement on a 1.5-T scanner to evaluate ventricular function and morphology, fatty infiltration and regional myocardial fibrosis in 52 subjects with suspected ARVD. Results Eight subjects met the international diagnostic criteria for ARVD. Right ventricle (RV) delayed hyper-enhancement was found in 7 of 8 (88%) ARVD subjects compared to 6 of 44 (14%) subjects without ARVD ( p < 0.001). Fatty infiltration was only identified in 1 ARVD patient, and 1 non-ARVD patient. On multiple logistic regression analysis RV enhancement remained an independent predictor for the diagnosis of ARVD ( p < 0.05). Conclusion RV delayed enhancement is common in patients with ARVD, whereas detection of fatty infiltration of the right ventricle was rare in our patient population. The inclusion of RV fibrosis on CMR as a feature of ARVD may improve the diagnostic accuracy of this condition.</description><identifier>ISSN: 1443-9506</identifier><identifier>EISSN: 1444-2892</identifier><identifier>DOI: 10.1016/j.hlc.2008.03.085</identifier><identifier>PMID: 18538631</identifier><language>eng</language><publisher>Australia: Elsevier B.V</publisher><subject>Adult ; Arrhythmogenic Right Ventricular Dysplasia - diagnosis ; Arrhythmogenic Right Ventricular Dysplasia - pathology ; ARVD ; Cardiac magnetic resonance imaging ; Cardiovascular ; Cohort Studies ; Delayed enhancement ; Fatty infiltration ; Female ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Sensitivity and Specificity ; Young Adult</subject><ispartof>Heart, lung & circulation, 2008-12, Vol.17 (6), p.478-483</ispartof><rights>Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand</rights><rights>2008 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-54833ebcb5d60f34da8a8cc4b9f67cf922fcba55c76c1fc4493c73e2520d05063</citedby><cites>FETCH-LOGICAL-c406t-54833ebcb5d60f34da8a8cc4b9f67cf922fcba55c76c1fc4493c73e2520d05063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18538631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pfluger, Heinz B., MD</creatorcontrib><creatorcontrib>Phrommintikul, Arintaya, MD</creatorcontrib><creatorcontrib>Mariani, Justin A., FRACP</creatorcontrib><creatorcontrib>Cherayath, Joshi G., Dip. AMIT</creatorcontrib><creatorcontrib>Taylor, Andrew J., PhD</creatorcontrib><title>Utility of Myocardial Fibrosis and Fatty Infiltration Detected by Cardiac Magnetic Resonance Imaging in the Diagnosis of Arrhythmogenic Right Ventricular Dysplasia—A Single Centre Experience</title><title>Heart, lung & circulation</title><addtitle>Heart Lung Circ</addtitle><description>Introduction Cardiac magnetic resonance imaging (CMR) has evolved as a major diagnostic tool to evaluate arrhythmogenic right ventricular dysplasia (ARVD). However, there is a lack of consensus in the interpretation of findings such as fatty infiltration or myocardial fibrosis. We examined the diagnostic utility of these two features in the diagnosis of ARVD. Methods We performed fast imaging employing steady-state acquisition cine imaging, T1 -weighted black blood imaging with and without fat suppression and post-contrast delayed enhancement on a 1.5-T scanner to evaluate ventricular function and morphology, fatty infiltration and regional myocardial fibrosis in 52 subjects with suspected ARVD. Results Eight subjects met the international diagnostic criteria for ARVD. Right ventricle (RV) delayed hyper-enhancement was found in 7 of 8 (88%) ARVD subjects compared to 6 of 44 (14%) subjects without ARVD ( p < 0.001). Fatty infiltration was only identified in 1 ARVD patient, and 1 non-ARVD patient. On multiple logistic regression analysis RV enhancement remained an independent predictor for the diagnosis of ARVD ( p < 0.05). Conclusion RV delayed enhancement is common in patients with ARVD, whereas detection of fatty infiltration of the right ventricle was rare in our patient population. The inclusion of RV fibrosis on CMR as a feature of ARVD may improve the diagnostic accuracy of this condition.</description><subject>Adult</subject><subject>Arrhythmogenic Right Ventricular Dysplasia - diagnosis</subject><subject>Arrhythmogenic Right Ventricular Dysplasia - pathology</subject><subject>ARVD</subject><subject>Cardiac magnetic resonance imaging</subject><subject>Cardiovascular</subject><subject>Cohort Studies</subject><subject>Delayed enhancement</subject><subject>Fatty infiltration</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging, Cine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sensitivity and Specificity</subject><subject>Young Adult</subject><issn>1443-9506</issn><issn>1444-2892</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9ksGO0zAQhiMEYpeFB-CCfOLWYMdJmggJqWq3UGlXSCzL1XImk3aK63RtF5EbD8ED8Sw8CU5bCYkDJ_vw_f9o_n-S5KXgqeCifLNNNwbSjPMq5TLlVfEouRR5nk-yqs4eH_9yUhe8vEieeb_lXExzWT9NLkRVyKqU4jL5dR_IUBhY37HboQftWtKGLalxvSfPtG3ZUocIrGxHJjgdqLdsgQEhYMuagc2PGmC3em0xELBP6HurLSBb7fSa7JqRZWGDbEEROdrGaTPnNkPY7Po12lFE601gX9AGR3Aw2rHF4PdGe9K_f_ycsbvoY5DNRwDZ9fc9OsI443nypNPG44vze5XcL68_zz9Mbj6-X81nNxPIeRkmRV5JiQ00RVvyTuatrnQFkDd1V06hq7Osg0YXBUxLEB3keS1hKjErMt7ymKC8Sl6ffPeufzigD2pHHtAYbbE_eFXWlZCSFxEUJxBigt5hp_aOdtoNSnA11qa2KtamxtoUlyrWFjWvzuaHZoftX8W5pwi8PQEYV_xG6JSH4_otuViEanv6r_27f9RgKIauzVcc0G_7g7MxOyWUzxRXd-PdjGfDq3gyWSnkH_xIwk0</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Pfluger, Heinz B., MD</creator><creator>Phrommintikul, Arintaya, MD</creator><creator>Mariani, Justin A., FRACP</creator><creator>Cherayath, Joshi G., Dip. AMIT</creator><creator>Taylor, Andrew J., PhD</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Utility of Myocardial Fibrosis and Fatty Infiltration Detected by Cardiac Magnetic Resonance Imaging in the Diagnosis of Arrhythmogenic Right Ventricular Dysplasia—A Single Centre Experience</title><author>Pfluger, Heinz B., MD ; Phrommintikul, Arintaya, MD ; Mariani, Justin A., FRACP ; Cherayath, Joshi G., Dip. AMIT ; Taylor, Andrew J., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-54833ebcb5d60f34da8a8cc4b9f67cf922fcba55c76c1fc4493c73e2520d05063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Arrhythmogenic Right Ventricular Dysplasia - diagnosis</topic><topic>Arrhythmogenic Right Ventricular Dysplasia - pathology</topic><topic>ARVD</topic><topic>Cardiac magnetic resonance imaging</topic><topic>Cardiovascular</topic><topic>Cohort Studies</topic><topic>Delayed enhancement</topic><topic>Fatty infiltration</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging, Cine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sensitivity and Specificity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfluger, Heinz B., MD</creatorcontrib><creatorcontrib>Phrommintikul, Arintaya, MD</creatorcontrib><creatorcontrib>Mariani, Justin A., FRACP</creatorcontrib><creatorcontrib>Cherayath, Joshi G., Dip. AMIT</creatorcontrib><creatorcontrib>Taylor, Andrew J., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart, lung & circulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfluger, Heinz B., MD</au><au>Phrommintikul, Arintaya, MD</au><au>Mariani, Justin A., FRACP</au><au>Cherayath, Joshi G., Dip. AMIT</au><au>Taylor, Andrew J., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of Myocardial Fibrosis and Fatty Infiltration Detected by Cardiac Magnetic Resonance Imaging in the Diagnosis of Arrhythmogenic Right Ventricular Dysplasia—A Single Centre Experience</atitle><jtitle>Heart, lung & circulation</jtitle><addtitle>Heart Lung Circ</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>17</volume><issue>6</issue><spage>478</spage><epage>483</epage><pages>478-483</pages><issn>1443-9506</issn><eissn>1444-2892</eissn><abstract>Introduction Cardiac magnetic resonance imaging (CMR) has evolved as a major diagnostic tool to evaluate arrhythmogenic right ventricular dysplasia (ARVD). However, there is a lack of consensus in the interpretation of findings such as fatty infiltration or myocardial fibrosis. We examined the diagnostic utility of these two features in the diagnosis of ARVD. Methods We performed fast imaging employing steady-state acquisition cine imaging, T1 -weighted black blood imaging with and without fat suppression and post-contrast delayed enhancement on a 1.5-T scanner to evaluate ventricular function and morphology, fatty infiltration and regional myocardial fibrosis in 52 subjects with suspected ARVD. Results Eight subjects met the international diagnostic criteria for ARVD. Right ventricle (RV) delayed hyper-enhancement was found in 7 of 8 (88%) ARVD subjects compared to 6 of 44 (14%) subjects without ARVD ( p < 0.001). Fatty infiltration was only identified in 1 ARVD patient, and 1 non-ARVD patient. On multiple logistic regression analysis RV enhancement remained an independent predictor for the diagnosis of ARVD ( p < 0.05). Conclusion RV delayed enhancement is common in patients with ARVD, whereas detection of fatty infiltration of the right ventricle was rare in our patient population. The inclusion of RV fibrosis on CMR as a feature of ARVD may improve the diagnostic accuracy of this condition.</abstract><cop>Australia</cop><pub>Elsevier B.V</pub><pmid>18538631</pmid><doi>10.1016/j.hlc.2008.03.085</doi><tpages>6</tpages></addata></record> |
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subjects | Adult Arrhythmogenic Right Ventricular Dysplasia - diagnosis Arrhythmogenic Right Ventricular Dysplasia - pathology ARVD Cardiac magnetic resonance imaging Cardiovascular Cohort Studies Delayed enhancement Fatty infiltration Female Humans Magnetic Resonance Imaging, Cine Male Middle Aged Sensitivity and Specificity Young Adult |
title | Utility of Myocardial Fibrosis and Fatty Infiltration Detected by Cardiac Magnetic Resonance Imaging in the Diagnosis of Arrhythmogenic Right Ventricular Dysplasia—A Single Centre Experience |
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