Anoikis: A necessary death program for anchorage-dependent cells

Cell to matrix adhesion is a key factor for cellular homeostasis and disruption of such interaction has adverse effects on cell survival. It leads to a specific type of apoptosis known as “anoikis” in most non-transformed cell types. This kind of apoptosis following loss of cell anchorage is importa...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical pharmacology 2008-12, Vol.76 (11), p.1352-1364
Main Authors: Chiarugi, Paola, Giannoni, Elisa
Format: Article
Language:English
Subjects:
Anchorage-dependent and -independent growth
Anoikis
Anoikis-resistance
Biological and medical sciences
Cell Adhesion
Homeostasis
Integrin signal transduction
Integrins - metabolism
Medical sciences
Neoplasm Metastasis
Pharmacology. Drug treatments
Reactive oxygen species
Reactive Oxygen Species - metabolism
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cell to matrix adhesion is a key factor for cellular homeostasis and disruption of such interaction has adverse effects on cell survival. It leads to a specific type of apoptosis known as “anoikis” in most non-transformed cell types. This kind of apoptosis following loss of cell anchorage is important for development, tissue homeostasis and several diseases. Integrins sense mechanical forces arising from the matrix, thereby converting these stimuli to downstream signals modulating cell viability. Anchorage-independent growth is a crucial step during tumorigenesis and in particular during the metastatic spreading of cancer cells. The disruption of the tight control leading an “homeless” cell to death is therefore able to violate the cell defences against transformation. This review analyses the recent investigations into the molecular mechanisms governing anoikis, discussing the different ways in which adhesion can influence this process and addressing the relevance of this unique apoptosis mode in the development of metastatic cancers, as well as in other diseases.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2008.07.023