Effect of Cibenzoline and Atenolol Administration on Dynamic Left Ventricular Obstruction Due to Sigmoid-Shaped Septum

Obstruction of the left ventricular outflow tract (LVOT) is usually complicated by hypertrophic cardiomyopathy or left ventricular hypertrophy. It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of t...

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Bibliographic Details
Published in:Circulation Journal 2008, Vol.72(12), pp.2087-2091
Main Authors: Ozaki, Kazuyuki, Sakuma, Ikki, Mitsuma, Koko, Suzuki, Tomoyasu, Tsuchida, Keiichi, Takahashi, Kazuyoshi, Miida, Tsutomu, Oda, Hirotaka
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Aged
Aging - pathology
Anti-Arrhythmia Agents - therapeutic use
Atenolol - therapeutic use
Blood Pressure - drug effects
Cibenzoline
Drug Therapy, Combination
Dyspnea - drug therapy
Dyspnea - etiology
Echocardiography, Doppler
Electrocardiography
Exercise Test
Exercise Tolerance - drug effects
Heart Septum - pathology
Humans
Imidazoles - therapeutic use
Left ventricular outflow obstruction
Male
Middle Aged
Pressure gradient
Sigmoid-shaped septum
Treatment Outcome
Ventricular Function, Left - drug effects
Ventricular Outflow Obstruction - drug therapy
Ventricular Outflow Obstruction - etiology
Ventricular Outflow Obstruction - pathology
Ventricular Outflow Obstruction - physiopathology
Ventricular Pressure - drug effects
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Summary:Obstruction of the left ventricular outflow tract (LVOT) is usually complicated by hypertrophic cardiomyopathy or left ventricular hypertrophy. It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of the LVOT were observed. Their complaints were dyspnea on effort and exercise increased the left ventricular pressure gradient. In both cases, atenolol administration decreased rest pressure gradient. Moreover, additional cibenzoline administration decreased the pressure gradient caused by exercise. It is emphasized that dual therapy with cibenzoline and atenolol is effective in resolving the obstruction of the LVOT caused by SS. (Circ J 2008; 72: 2087 - 2091)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-07-0897