The diagnostic value of café-au-lait macules

Single café-au-lait macules (CALMs) are common in the pediatric population and in most children represent a normal finding. It is important to recognize whether the presence of multiple CALMs in a particular patient is normal or indicates an association with a multisystem disorder. This article addr...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1999-06, Vol.40 (6), p.877-890
Main Authors: Landau, Marina, Krafchik, Bernice R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cafe-au-Lait Spots - complications
Cafe-au-Lait Spots - diagnosis
Cafe-au-Lait Spots - genetics
Dermatology
Humans
Medical sciences
Syndrome
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Single café-au-lait macules (CALMs) are common in the pediatric population and in most children represent a normal finding. It is important to recognize whether the presence of multiple CALMs in a particular patient is normal or indicates an association with a multisystem disorder. This article addresses issues concerning the prevalence, genetics, and natural history of CALMs in the general population and reviews disorders in which CALMs are present as a characteristic trait. (J Am Acad Dermatol 1999;40:877-90.) Learning Objective: At the completion of this learning activity, participants should be familiar with the clinical and histologic aspects of café-au-lait macules and the prevalence, genetics, and natural history of them, particularly in children.
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(99)70075-7