Estrogen actions in the central nervous system

This article will review the neural actions of estrogens in the central nervous system, focusing on brain structures outside of the hypothalamus and on neurally mediated processes other than reproductive behavior and reproductive neuroendocrine events. We do this, however, in the context of what is...

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Bibliographic Details
Published in:Endocrine reviews 1999-06, Vol.20 (3), p.279-307
Main Authors: McEwen, B S, Alves, S E
Format: Article
Language:English
Subjects:
Alzheimer Disease
Animals
Central Nervous System - cytology
Central Nervous System - drug effects
Central Nervous System - physiology
Estrogens - pharmacology
Estrogens - physiology
Female
Gene Expression Regulation - drug effects
Humans
Hypothalamus - cytology
Hypothalamus - drug effects
Hypothalamus - physiology
Learning - drug effects
Memory - drug effects
progestin
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Summary:This article will review the neural actions of estrogens in the central nervous system, focusing on brain structures outside of the hypothalamus and on neurally mediated processes other than reproductive behavior and reproductive neuroendocrine events. We do this, however, in the context of what is known about estrogen actions in the hypothalamus. In this summary of the recent scientific literature, we place particular emphasis on estrogen and progestin effects in the hippocampal formation, as well as basal forebrain of the rat, because these brain structures are prominent in learning and memory and also are sites of neural degeneration in dementing illnesses such as Alzheimer's disease.
ISSN:0163-769X
DOI:10.1210/er.20.3.279